| Issue |
BIO Web Conf.
Volume 142, 2024
2024 International Symposium on Agricultural Engineering and Biology (ISAEB 2024)
|
|
|---|---|---|
| Article Number | 03013 | |
| Number of page(s) | 5 | |
| Section | Microbial Engineering and Biomedical Exploration | |
| DOI | https://doi.org/10.1051/bioconf/202414203013 | |
| Published online | 21 November 2024 | |
Therapeutic Effect of Polygonum multiflorum Extract on Gouty Arthritis in Rats
1 Clinical College, Changsha Medical University, Changsha, Hunan 410219, China
2 Basic Medical College, Changsha Medical University, Changsha, Hunan 410219, China
* Corresponding author: helian4260@sina.com; a2971651278@qq.com; b435644011@qq.com
Objective: The investigation of the efficacy of Polygonum multiflorum extract on gouty arthritis in rats. Method: Thirty male SD rats were randomly divided into blank control group, gouty arthritis model group, colchicine group, low, medium, and high dose groups of Polygonum multiflorum extract. Rats in the colchicine group and Polygonum multiflorum extract treatment groups were gavaged with colchicine and different concentrations of Polygonum multiflorum extract for 16 consecutive days, respectively. During this period, the blank control group was gavaged with an equal amount of physiological saline. On the 14th day, an acute gouty arthritis rat model was established by injecting sodium urate solution into the ankle joint cavity of rats. The blank control group was injected with an equal amount of physiological saline. After modeling, the ankle circumference of each group of rats was measured at different time points, and the degree of joint swelling was calculated. After the experiment, anesthetized the animals and collected blood samples from each group of animals. The serum uric acid (UA) content and xanthine oxidase (XOD) activity of the rats were detected using a reagent kit. Result: The degree of ankle joint swelling in the model group rats was significantly higher than that in the blank control group at various time points (P < 0.05), indicating the successful establishment of a gouty arthritis animal model. Compared with the model group, extracts of colchicine and Polygonum multiflorum can significantly reduce ankle joint swelling in rats with gouty arthritis (P < 0.05). Compared with the blank control group, the serum levels of UA and XOD in the model group rats were significantly increased (P < 0.05); Both colchicine and Polygonum multiflorum extract can significantly reduce the levels of UA and XOD in the serum of gouty arthritis model rats (P < 0.05). Conclusion: The present study has demonstrated the therapeutic efficacy of Polygonum multiflorum extract in the treatment of gouty arthritis, thus establishing a scientific basis for its potential utilization as a clinical pharmaceutical agent for managing this condition.
© The Authors, published by EDP Sciences, 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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