Issue |
BIO Web Conf.
Volume 151, 2025
International Conference “Mountains: Biodiversity, Landscapes and Cultures” (MBLC-2024)
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Article Number | 01015 | |
Number of page(s) | 5 | |
Section | Agriculture and Ecology | |
DOI | https://doi.org/10.1051/bioconf/202515101015 | |
Published online | 21 January 2025 |
Impact of Insolation on Melatonin, Sleep Disorders, Cerebral Ischemia, and Cognitive Functions
Tashkent Medical Academy, Tashkent, Uzbekistan
* Corresponding author: zufargms@mail.ru
The article explores the effect of insolation on the level of serum melatonin, sleep disorders, chronic cerebral ischemia and cognitive functions. Eighty patients with chronic cerebral ischemia (CCI) were examined. The average age of the patients was 58.5±1.4 years. The patients were divided into 6 groups depending on the presence of sleep disorders and the stage of CCI. The concentration of melatonin in the blood was studied depending on the season. Sleep disorders and cognitive impairment were assessed using special questionnaires, and cognitive evoked potentials P300 were studied. To correct sleep disorders, patients took melatonin. The concentration of melatonin in the blood is subject to seasonal changes in the duration of daylight, with maximum values in winter and minimum in summer. With increasing age and severity of cerebral ischemia, a decrease in the concentration of melatonin in the blood is observed. As the severity of CCI increases, cognitive indices deteriorate, as indicated by questionnaires and cognitive evoked potentials, which show an increase in P300 latency. Additionally, daytime sleepiness, as measured by the Epworth scale, also tends to worsen. Sleep disturbance in patients with CCI leads to a decrease in cognitive functions.
Key words: insolation / seasonality / sleep disorders / cognitive impairment / cognitive evoked potentials / chronic cerebral ischemia / melatonin
© The Authors, published by EDP Sciences, 2025
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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