Exploring the Competitive Relationship of Pattern Separation Training and External Stress on Building Synapses with ABN and it’s Molecular Mechanisms

School of Radiology and Protection, Soochow University, Suzhou 215123, China

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Abstract

Previous studies have shown that pattern separation training can play an antidepressant role, but the underlying mechanism is not clear. The ability of pattern separation is affected by newborn neurons, which also affect the treatment of depression. Thus, there is a structural hierarchical association between pattern separation ability and depression. That is, at the structural level of newborn neurons, pattern separation and depression may be able to interact. To investigate the mechanism by which pattern separation training plays an antidepressant effect, this paper tries to start with the factors influencing the pattern separation ability and the level of depression. In the paper, we choose pattern separation training and stress as the key influencing factors. We propose that the reason why pattern separation training can have antidepressant effect is partly because the competitive relationship between pattern separation training and external stress on building synapses.