| Issue |
BIO Web Conf.
Volume 174, 2025
2025 7th International Conference on Biotechnology and Biomedicine (ICBB 2025)
|
|
|---|---|---|
| Article Number | 01007 | |
| Number of page(s) | 5 | |
| Section | Advances in Molecular Biology and Genetic Research | |
| DOI | https://doi.org/10.1051/bioconf/202517401007 | |
| Published online | 12 May 2025 | |
Epigenetic Regulation of Mesenchymal Stem Cell Differentiation and the role of external response
1 Stomatology, Jitang College of North China University of Science and Technology, Hebei, 063210, China
2 Stomatology, Clinical College of Hebei Medical University, Hebei, 050031, China
* Corresponding author's e-mail: 13143639051@163.com
Mesenchymal stem cells (MSCs) possess important physiological characteristics such as self- proliferation and multipotent differentiation potential, making them highly promising for applications in tissue repair and regeneration. However, the precise mechanisms underlying these properties remain obscure. Epigenetics is a key clue, which works through DNA methylation, histone modifications, and RNA methylation, regulating MSC gene expression without altering the DNA sequence. These modifications have a significant impact on the fate and function of MSC differentiation, determining their multipotent capabilities. This review explores the role and regulatory mechanisms of epigenetics in MSC differentiation, its direct impact on clinical applications such as advancements in regenerative medicine, and how external factors such as mechanical forces, materials, and other environmental conditions influence MSCs through epigenetic modifications.
© The Authors, published by EDP Sciences, 2025
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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