| Issue |
BIO Web Conf.
Volume 174, 2025
2025 7th International Conference on Biotechnology and Biomedicine (ICBB 2025)
|
|
|---|---|---|
| Article Number | 01022 | |
| Number of page(s) | 8 | |
| Section | Advances in Molecular Biology and Genetic Research | |
| DOI | https://doi.org/10.1051/bioconf/202517401022 | |
| Published online | 12 May 2025 | |
Mechanism Study of Prussian Blue Nanozymes in the Treatment of Crohn's Disease Based on Metagenomic Analysis
School of Biological Science and Medical Engineering, Southeast University, National Key Laboratory of Digital Medical Engineering, Nanjing, China, 210096
* Corresponding author: whitecf@seu.edu.cn
Crohn's Disease (CD) is a type of inflammatory bowel disease (IBD) with an unknown etiology, characterized by gastrointestinal immune-related inflammation. Currently, there is no specific drug for treating IBD, and existing treatments only alleviate symptoms with significant side effects that vary among individuals. Numerous studies have shown a close relationship between gut microbiota and Crohn's disease. However, due to the unclear pathogenesis of Crohn's disease, microbial-based therapies have not been widely adopted. In this study, we used a TNBS (2, 4, 6-trinitrobenzene sulfonic acid)-induced rat model of Crohn's disease to treat the model group with Prussian Blue Nanozymes (PB). Based on metagenomic analysis, we examined the diversity, community changes, and species differences in gut microbiota before and after treatment, identifying 20 disease-related species, 16 PB treatment-related species, and significant community changes. This provides insights for further understanding the pathogenesis of Crohn's disease and the therapeutic mechanisms of Prussian Blue Nanozymes.
© The Authors, published by EDP Sciences, 2025
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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