Localised drug delivery for the treatment of cervical cancer

¹ University of Washington, Seattle 98195-3770, America
² Suzhou University, Suzhou 215031, China
³ University of Nottingham Ningbo China, Ningbo 315000, China

1zliu68@uw.edu 21229150313@qq.com 3ssyjy9@nottingham.edu.cn

Abstract

Cancer is often treated by surgical intervention, in later stages needs adjuvant chemotherapy or radiation therapy. The position of cervix is easy for drug to localized delivered through the vagina, which directly targets the action site, decreasing the dosage and systemic side effects. This method is good for fertility maintenance, because it allows for the removal of smaller tumors, thereby lowering the risk of premature labour. Additionally, localized delivery post-surgery can help greatly reduce recurrence rates, providing a better fertility protecting results compared to traditional surgery. This paper summarizes the development of targeted drug delivery systems in the past five years, and the results show that targeted drug delivery can improve the therapeutic efficiency of drugs and reduce side effects by improving drug accuracy and reducing side effects. In addition, various targeting methods are discussed, including passive targeting, physical targeting, active targeting. Their respective roles in improving therapeutic effectiveness are also be discussed. There are two main problems encountered during drug delivery, one is the ability to carry enough drug to treat, this will be solved by the choice of liposomes to be used and the second is the ability to protect the successful delivery of the drug to the organ that needs to be treated, and to solve this problem will be aided by the further addition of Carbopol as well as other substances to the liposomes. the main approach used in this article is the different methods used to prepare liposomes with different substances to counteract the substances in the vagina.