| Issue |
BIO Web Conf.
Volume 191, 2025
The 6th International Conference on Environmentally Sustainable Animal Industry and The 6th Animal Production International Seminar (ICESAI APIS 2025)
|
|
|---|---|---|
| Article Number | 00043 | |
| Number of page(s) | 7 | |
| DOI | https://doi.org/10.1051/bioconf/202519100043 | |
| Published online | 20 October 2025 | |
Effect of Chitosan Oligosaccharide (COS) Supplementation on TLR4 Gene Expression, Blood Profil, and Carcass Weight in Broiler Chicken
1 Faculty of Animal Sciences, Universitas Brawijaya, Malang 65145, Indonesia
2 Faculty of Animal Sciences, IPB University, Bogor 16680, Indonesia
* Corresponding author: poppypuspita@ub.ac.id
This study was carried out to evaluate Chitosan Oligoshaccarida (COS) supplementation on TLR4 gene expression, blood profile, and carcass weight in broiler chicken. A total of 100 Lohmann broiler Day Old Chick (DOC) with an initial average body weight of 46 ± 0.7 g were randomly allotted into 2 group treatments with 5 replications (10 unsexed DOC in each pen) for 35 days. Dietary treatments were Basal Diet (BD) without supplement (P0) and BD + COS 100 mg kg-1 (P1). The results showed that treatments with COS 100 mg kg-1 decrease TLR4 mRNA expression level compared to control, but were not differ on blood profile and the ratio between heterophils and lymphocytes which ranged from 0.58-0.87 indicated that chickens experienced moderate to high stress. COS supplementation had the significant differences in carcass weight, where chickens given COS supplementation had a higher carcass weight than the control. In conclusion COS supplementation in broiler feed can significantly increase carcass weight and improve the health status of chickens as seen from blood profile and TLR4 gene expression.
Key words: Broiler Chickens / Chitosan Oligosaccharide / TLR4 Gene / Performance
© The Authors, published by EDP Sciences, 2025
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