Therapeutic efficacy of a drug for the antimicrobial treatment of cattle hooves

Federal Center for Toxicological, Radiation and Biological Safety, 2 NauchnyGorodok, Kazan, 420075, Russia

^* Corresponding author: evgenechka1885@gmail.com

Abstract

This paper presents a technology for producing a metal complex gel preparation for the antimicrobial treatment of cattle hooves with distal extremity diseases and a study of its effectiveness under production conditions. The proposed production method allows for the production of a gel preparation that is environmentally friendly, simple, and inexpensive, and does not require complex chemical synthesis. After using the developed preparation, improvements in the animals’ clinical condition and reduced wound healing time correlated with the severity of the clinical picture of the disease and a reduction in the number and species of microorganisms in smears of biological material from the affected hooves. Thus, while prior to administration of the drug to cows with limb diseases, among a wide variety of opportunistic microorganisms detected, the count of one or more of their representatives (F. necrohorum, Streptococcus spp., Staphylococcus spp., Clostridium spp., Aspergillus spp., Penicillium spp., Mucor spp. and Candida albicans) exceeded threshold values (more than 1x10⁴ colony-forming units), after administration of the drug, vegetative forms of bacteria and microscopic fungi were completely absent in cows with mild and moderate disease severity, while spore-forming and anaerobic bacteria continued to be detected in animals with severe disease. The gel form of the drug created a mechanical barrier, preventing microorganism adhesion to tissues, reducing microbial concentrations, and preventing the development of infection, which opens up new opportunities for maintaining the health and productive longevity of cattle.