Action mechanisms and cattle breeding potential of Baihe Wuyao Xiexin decoction

¹ Polessky State University, Pinsk, Republic of Belarus
² All-Russian Research Institute of Physiology, Biochemistry and Nutrition of Animals – Branch of the Federal Research Center for Animal Husbandry named after Academy Member L. K. Ernst, Borovsk, Russia
³ Scientific and Practical Center of the National Academy of Sciences of Belarus for Animal Breeding RUE, 11, Frunze str., Zhodino, Minsk region, Republic of Belarus
⁴ State Key Laboratory of Brain Function and Disorders, Institutes of Brain Science, MOE Frontier Center for Brain Science, Fudan University, Shanghai 200032, China
⁵ The Second Clinical College of Guangzhou University of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, China
⁶ International Sakharov Environmental Institute, Belarusian State University, 220070, Minsk, Belarus

¹ Corresponding author: 31773044@qq.com

Abstract

This study aimed to investigate the molecular mechanisms of the Baihe Wuyao Xiexin Decoction in treating esophagitis. The objectives were to identify its key active ingredients and core targets, establish a comprehensive “compound-target-pathway” network, and explore its potential application in beef cattle farming. In this study, network pharmacology combined with molecular docking technology was used to investigate Baihe Wuyao Xiexin Decoction. A “drug-component-target- pathway-esophagitis” network was constructed to systematically analyze the potential mechanism of the decoction in treating esophagitis, and the key active components, therapeutic targets, and related signaling pathways were identified. Meanwhile, based on the characteristics of the active components of the prescription and the needs of the beef cattle breeding industry, the application potential of its extract and herb residues in beef cattle breeding was further explored. The results of this study provide a scientific basis and theoretical support for the clinical application and further development of this prescription, as well as its industrialization in the field of green breeding.