| Issue |
BIO Web Conf.
Volume 203, 2025
International Conference Biotechnology on Tropical Environment (ICBTE 2025)
|
|
|---|---|---|
| Article Number | 01001 | |
| Number of page(s) | 9 | |
| Section | Bio Science → Life Sciences, Biodiversity, and Agricultural Biotechnology | |
| DOI | https://doi.org/10.1051/bioconf/202520301001 | |
| Published online | 11 December 2025 | |
Antibacterial activity of musa balbisiana peel extract against diabetic ulcer pathogens
1 Study Program of Nursing, Faculty of Health Science, Universitas Aisyiyah Yogyakarta, Yogyakarta, Indonesia
2 Study Program of Medical Laboratory Technology, Faculty of Health Science, Universitas Aisyiyah Yogyakarta, Yogyakarta, Indonesia
3 Study Program of Pharmacy, Faculty of Health Science, Universitas Muhammadiyah Magelang, Center Java, Indonesia
4 Study Program of Nursing Department, Faculty of Nursing and Health Science, Universitas Muhammadiyah Semarang, Center Java, Indonesia
* Corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.
Banana peel (Musa balbisiana) contains bioactive compounds with potential antimicrobial activity that may support diabetic ulcer management. This study aimed to evaluate the antibacterial activity of banana peel extracts and their cream formulations against ulcer-associated pathogens. Fresh and waste banana peel extracts were prepared using ethanol and methanol solvents, and phytochemical screening was performed. Antibacterial activity was tested against Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa using minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and disc diffusion assays. Cream formulations containing 1-4% extracts were also evaluated for physical characteristics. The results showed banana peel extracts contained alkaloids, flavonoids, tannins, and saponins. The MIC was observed at 4% and MBC at 10%, with more vigorous activity against Gram-positive bacteria (S. aureus, S. epidermidis) than Gram-negative (P. aeruginosa). Methanol extracts exhibited higher activity compared to ethanol extracts. Cream formulations demonstrated acceptable spread ability (5.5-7.0 cm), adhesion (1.5-2.7 s), and skin-compatible pH (5.0-6.0). These findings suggest that banana peel extracts possess promising antibacterial potential and can be developed into topical formulations for diabetic ulcer management. Further in vivo and clinical studies are needed to validate efficacy.1
© The Authors, published by EDP Sciences, 2025
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