Expression profiles of interleukin-6, c-reactive protein, and rheumatoid factor in pre and menopause osteoarthritis patients

¹ Program Studi of Midwifery, Faculty of Health Science, Aisyiyah University of Yogyakarta, Yogyakarta, Indonesia
² Program Studi of Medical Laboratoty, Faculty of Health Science, Aisyiyah University of Yogyakarta, Yogyakarta, Indonesia

^* Corresponding author: nuli.zulala@unisayogya.ac.id

Abstract

Osteoarthritis (OA) is a disease that results from damage to the cartilage covering the bones, leading to friction between bones during movement. The inflammation in OA includes the production of several pro-inflammatory cytokines, such as interleukin 6 (IL-6). As the disease progresses, it can lower quality of life, reduce life expectancy, and create a financial burden for those affected. This study aimed to examine the effect of age on OA by looking at the expression levels of IL-6, c-reactive protein (CRP), and rheumatoid factor (RF) in participants. Methods: This descriptive cross-sectional study involved 20 female participants aged 40 and older. We measured IL-6 levels using ELISA (Enzyme-Linked Immunosorbent Assay). For CRP and RF, we used latex agglutination tests. Results: Age did not impact the occurrence of osteoarthritis (p value: 0.624). IL-6 levels were higher in the group without OA. Most samples showed negative results for CRP and RF. Conclusion: Elevated IL-6 levels are not exclusive to OA patients; several factors, like exercise, can also raise IL-6 levels. Most samples did not show significant systemic inflammation, as indicated by low CRP and RF levels.