Development Of Technology of Dry Extract of Purple Echinacea for Obtaining the Active Pharmacological Ingredient “Immunaship”

¹ Department of Pharmacology, Tashkent State Medical University, Tashkent, Republic of Uzbekistan
² Department of Pharmacology, Termez Branch of Tashkent State Medical University, Termez, Republic of Uzbekistan
³ Department of Pharmaceutical Chemistry, Tashkent Pharmaceutical Institute, Tashkent, Republic of Uzbekistan
⁴ Pharmacognosy, Technology of Medicines and Biotechnology department, State Institution “Scientific Research Pharmaceutical Center”, Dushanbe, Tajikistan.

^* Corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Modem drug development benefits considerably from biologically active onstituents found in medicinal plants. This study formulates a powdered extract named Immunaship, produced through extraction of Echinacea purpurea combined with rosehip fruits, both known for supporting immune function. Existing extraction techniques for plant-based immunostimulants often fail to achieve high concentrations of biologically active compounds while maintaining stable physical and chemical properties.

Researchers applied bismaceration for polyextraction, followed by HPLC analysis and spectrophotometric evaluation of the extract’s composition. The assessment included fractional composition, bulk density, flowability, angle of repose, and moisture content. The resulting dry extract contains six key compounds—chlorogenic acid, rutin, caffeic acid, cynaroside, luteolin, and quercetin—along with a phenylpropanoid level of 1.35%, expressed as chicoric acid. Elemental analysis confirmed the presence of essential minerals such as potassium, calcium, magnesium, and iron, which enhance the sample’s biological value. Excipients must be incorporated to improve formulation stability and improve the powder’s flow characteristics.