| Issue |
BIO Web Conf.
Volume 232, 2026
2026 16th International Conference on Bioscience, Biochemistry and Bioinformatics (ICBBB 2026)
|
|
|---|---|---|
| Article Number | 06002 | |
| Number of page(s) | 10 | |
| Section | AI-Driven Biomedical Text Mining and Intelligent Disease Diagnosis | |
| DOI | https://doi.org/10.1051/bioconf/202623206002 | |
| Published online | 24 April 2026 | |
Parkinson’s Disease Detection Through Static Handwriting Analysis Using CNNs and SVM Ensemble
University of San Carlos, Gov. M. Cuenco Avenue, Talamban, Cebu City, Philippines
1 Corresponding author: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Parkinson's Disease is a progressive neurological disorder marked by motor impairments, often reflected in handwriting anomalies such as tremors, micrographia, and stroke irregularities. The diagnosis often relies on subjective clinical evaluation. This study explores an objective detection framework using static handwriting samples, specifically spiral and wave drawings. The method employs an ensemble strategy that fuses deep features from two pre-trained Convolutional Neural Network (CNN) architectures, ResNet50 and DenseNet121, and classifies the feature representations using a Linear Support Vector Machine (SVM). To ensure rigor, a strict split-before-augmentation protocol was applied to a primary dataset of 204 subjects. The model achieved 97.28% accuracy on the primary test set. When independently verified using a local dataset, the system maintained strong generalization with an accuracy of 95.19%, 97.04% PD recall, and 93.33% specificity. Statistical analysis confirmed these results with narrow confidence intervals, validating the system's stability. The results confirm that dual-CNN feature fusion significantly improves detection stability and adaptability between datasets. This framework serves as an objective, scalable screening tool to complement neurological assessments.
© The Authors, published by EDP Sciences, 2026
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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