Dynamics of passive immunity formation against the causative agent of infectious bursal disease and its immunological significance

Samarkand State University of Veterinary Medicine, Livestock and Biotechnologies, M.Ulugbek, 77, Samarkand, 140103, Uzbekistan

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Abstract

In the study, the spread and pathogenetic features of Newcastle disease under industrial poultry farming conditions with high stocking density were analyzed. Investigated the impact of Newcastle disease virus on the respiratory, digestive, and central nervous systems of poultry. Revealed the role of maternally derived passive immunity in forming the initial level of protection in newly hatched chicks during the early postnatal period. Studied the dynamics of maternal antibody levels and the duration of their persistence in the organism of young birds at different developmental stages. Determined the influence of natal and postnatal developmental periods on the formation of the immune system and the functional activity of lymphoid organs. Established the dependence of the immune response to vaccination on the initial immune status and physiological condition of poultry. Formed an understanding of changes in immunological indicators during the growth and development of chicks under industrial conditions. Proposed the consideration of immunological monitoring results when designing preventive measures against the disease. Developed a rationale for optimizing vaccination schemes based on age-related and immunological characteristics of poultry. Substantiated the application of an integrated immunoprophylaxis approach aimed at increasing resistance to infection and reducing disease spread.