BIO Web Conf.
Volume 14, 2019The 12th International Conference on the Health Effects of Incorporated Radionuclides (HEIR 2018)
|Number of page(s)||1|
|Section||Epidemiology: Oral presentations|
|Published online||07 May 2019|
Association analysis between mortality and ionizing radiation exposure in French uranium workers
Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Laboratoire d’Epidémiologie des rayonnements ionisants (PSE-SANTE/SESANE/LEPID), Fontenay-aux-Roses, France
2 Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Laboratoire d’Evaluation de la Dose Interne (PSE-SANTE/SDOS/LEDI), Fontenay-aux-Roses, France
3 Amplexor, Montigny-le-Bretonneux, France
4 University of North Carolina, Chapel Hill, USA
5 Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-SANTE/SESANE, Fontenay-aux-Roses, France
* Corresponding author: email@example.com
To investigate associations between mortality and chronic internal and external exposure to ionizing radiation in a cohort of nuclear workers with potential for internal exposure to uranium.
Workers employed for at least six months in five plants involved in the French nuclear fuel cycle were included and followed up for mortality between 1968 and 2013. Cause-specific standardized mortality ratios were calculated for all workers. Internal and external absorbed doses were reconstructed for each worker with computerized information. Analyses of associations between radiation dose and cause-specific mortality were conducted using Poisson regression.
The cohort includes 4541 workers. At the end of the follow-up, 838 workers were deceased and 28 lost to follow-up. A healthy worker effect was observed. The risk of prostate cancer mortality was significantly higher for workers exposed to cumulative external dose higher than 50 mGy as compared to non-exposed, but this association became non-significant after adjustment for smoking. Associations between mortality and internal dose showed no consistent pattern. Except for prostate cancer mortality, adjustments for smoking and other risk factors rarely documented in cohorts of radiation workers had no marked influence on findings.
It is the first time in France that such a study was conducted in a cohort of uranium workers with a complete reconstruction of internal dose. Results should be considered as preliminary and interpreted with caution because of the limited size of the cohort and significant sources of uncertainty, notably on dose assessment. Future steps of this study will allow overcoming these limitations.
© The Authors, published by EDP Sciences, 2019
This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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