Open Access
Issue
BIO Web Conf.
Volume 14, 2019
The 12th International Conference on the Health Effects of Incorporated Radionuclides (HEIR 2018)
Article Number 04011
Number of page(s) 2
Section Epidemiology: Poster presentation
DOI https://doi.org/10.1051/bioconf/20191404011
Published online 07 May 2019

The diethylenetriaminepentaacetic acid (DTPA) is a chelating agent used to decorporate plutonium (Pu), americium (Am) and curium (Cm) after internal contamination. The DTPA-actinide chelate is mainly excreted in urines. Hence, DTPA decorporation therapy increases and accelerates actinide excretion, which results in a decrease in the actinide systemic retention. In France, Ca-DTPA has been used since 1962 and authorized by the French National Agency for Medicines and Health Products Safety (ANSM) since 2008 [1]. This authorization has been given upon the completion of a first study of French nuclear workers contaminated with Pu and/or Am and treated with injection(s) of DTPA. Data on contamination events, subsequent treatments and bioassays were collected and stored in a database. Main results of the data analysis included:

  • descriptive statistics on the 548 collected events of contamination and corresponding treatments protocols, which resulted in a total of 1158 injections,

  • an evaluation of the increase of urinary excretion,

  • a description of adverse reactions (cutaneous allergy) observed on only one case out of the 469 persons treated

  • a common treatment protocol,

  • a CEA report and several publications in peer-reviewed journals [1-5].

However, the systematic storage in this database of information on the monitoring and treatment of contaminated workers has been discontinued since the end of the first study in 2004. Still, while DTPA is the treatment of choice after Pu, Am and/or Cm contamination, it is necessary to keep on updating statistics on contamination conditions, treatment protocols, bioassay results and eventual adverse reactions. This information is crucial to optimize treatment protocols and to possibly adapt the protocol on the contamination conditions. It is also a solid foundation for communicating with workers in case a treatment is recommended. Furthermore, the interpretation of excretion data after DTPA treatment remains a challenging step in the estimation of internal dose. In the meantime, biokinetic models from the International Commission for Radiological Protection does not account for DTPA treatment. Therefore, collection of excretion data affected by DTPA treatment can contribute to current efforts for developing a biokinetic model that includes the effect of DTPA.

As additional cases of contamination and DTPA treatments have been observed in France in the past 14 years, it was therefore decided to update this database and re-initiate a study including these new data. A working group composed of occupational physicians, biologists, pharmacists, experts in internal dosimetry and data analysists from the French nuclear industry, has been created early 2018. While the objectives will be similar as the initial study, the approach will be completed. Whereas the first study reported measurement results only based on urine data, the whole set of radiotoxicological and in vivo measurement will be used. In particular, faecal measurements will be included as DTPA also results in an increase of faecal excretion, whereas this effect has not yet been thoroughly evaluated. The increase of urinary and faecal excretion after DTPA will be quantified and evaluated depending on the radioisotope and route of entry. A numerical code based on the R-project for statistical computing (www.r-project.org) will be used to carry out this analysis which will facilitate the traceability of the results.

References


© The Authors, published by EDP Sciences, 2019

Licence Creative Commons
This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.