BIO Web Conf.
Volume 14, 2019The 12th International Conference on the Health Effects of Incorporated Radionuclides (HEIR 2018)
|Number of page(s)||2|
|Section||What’s Next?: Oral presentations|
|Published online||07 May 2019|
USTUR: Expanding horizons for actinide biokinetics and dosimetry
U.S. Transuranium and Uranium Registries, College of Pharmacy, Washington State University, 1845 Terminal Drive, Suite 201, Richland
99354, WA, USA
* Corresponding author: firstname.lastname@example.org
Since 1968, the U.S. Transuranium and Uranium Registries (USTUR) has followed up with occupationally-exposed individuals (volunteer Registrants) by studying the biokinetics (deposition, translocation, retention, and excretion) and tissue dosimetry of actinide elements .
The USTUR holds data on work history, radiation exposure and bioassay measurements, as well as medical records from more than 400 former nuclear workers. These individuals had documented intakes of actinides at the levels higher than 74 Bq. Inhalation and wound are two major routes of intake and 239Pu is a primary radionuclide (Fig. 1.)
USTUR Registrants’ exposure by: route of intake (left) and primary radionuclide (right).
Post-mortem radiochemical analyses of tissues obtained at autopsy, especially those from the whole-body donors, allows USTUR to significantly improve our knowledge of distribution and long-term retention of actinides in the human body and have helped in parameterizing biokinetic constants for these radioactive elements.
Recently, several groups of individual cases have been identified for studying biokinetics and dosimetry for specific radionuclides, exposure scenarios and materials, as well as effects of decorporation treatment (Table 1).
USTUR specific study groups
Data from a USTUR whole-body donor who was exposed to soluble 239Pu via inhalation were used to study long-term plutonium retention in the upper airways and quantify the plutonium ‘bound’ fraction [2, 3]. This is only one notable example of the manner in which USTUR data can be used to improve accuracy of dose assessment and radiation protection of plutonium workers.
- The United States Transuranium and Uranium Registries. https://ustur.wsu.edu/ [Google Scholar]
- A. Birchall, M. Puncher, S. Y. Tolmachev. Radiat. Prot. Dosim. 176 , 50 (2017). [Google Scholar]
- A. Birchall, M. Puncher, A. Hodgson, S. Y. Tolmachev. Health Phys. Published Ahead-of-Print (2018). [Google Scholar]
© The Authors, published by EDP Sciences, 2019
This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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