Two-dimensional ¹H-¹³C Heternouclear Single Quantum Coherence (HSQC) experiments, applying a home-made water-to-ethanol multipresaturation scheme [12] used to detect novel metabolites with the addition of a ¹³C NMR dimension. Magenta: ¹H-¹³C HSQC of large-scaled fermented wines with Saccharomyces Bayanus ex uvarum ES-U42 strain; Black: ¹H-¹³C HSQC of large-scaled fermented wines with standard Saccharomyces Bayanus control; Blue: ¹H-¹³C HSQC of large-scaled fermented wines with Co-inoculation of Non-Saccharomyces Candida zemplinina (Enartis Ferm) with S. cerevisiae 10N45 strain. Bottom: ¹H-¹³C HSQC pulse program, with the addition of a multipresat module, prior to the INEPT polarization transfer module.