Pathogenetic substantiation of the combined transplantation use of multipotent mesenchymal stromal cells and hepatic stellate cells to restore the liver morphofunctional state after acute toxic hepatitis in the old body

Open Access

Table 1.

Morphometric liver indicators of old laboratory mice 3 days after CCl₄, M±m injection, n = 7

Indicators	Intact animals	Animals with toxic hepatitis
Indicators	NaCl	NaCl	MMSC+HSC
Number of hepatocytes per 1 mm²	1323.14±111.31	1431.29±116.33	1552.43±125.06
Area of hepatocytes, μm²	297.10±21.14	228.04±17.47^*	242.26±19.45^*
Hepatocyte nucleus area, μm²	57.60±5.37	70.54±5.34^*	87.51±7.87^* ^**
Area of hepatocyte cytoplasm, μm²	239.93±16.42	157.50±15.14^*	154.74±12.92^*
NCI	0.25±0.02	0.45±0.03^*	0.57±0.03^* ^**
Number of binuclear hepatocytes per mm²	241.06±21.38	736.14±56.37^*	913.86±85.84^* ^**
MI, %	0.40±0.05	6.80±0.51^*	7.53±0.71^*
AI, %	0.51±0.04	4.34±0.39^*	3,41±0.24^* ^**
Number of hepatocytes with micronucleus, %	3.20±0.20	8.43±0.62^*	6.04±0.59^* ^**

Note: * reliable with p<0.05 unlike the intact group of old laboratory animals ** reliable with p<0.05 unlike the control group of old laboratory animals.

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