APOE-ε4 genes may accelerate the activation of the latent form of HSV-1 which would lead to a faster progression of AD

Open Access

Issue		BIO Web Conf. Volume 72, 2023 2023 International Conference on Food Science and Bio-medicine (ICFSB 2023)


Article Number		01006
Number of page(s)		7
Section		Food Ingredients Application and Food Safety Identification
DOI		https://doi.org/10.1051/bioconf/20237201006
Published online		08 November 2023

Christensen, D. Z., Kraus, S. L., Flohr, A., Cotel, M.C., Wirths, O., & Bayer, T. A. (2008). Transient intraneuronal Aβ rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice. Acta Neuropathologica, 116(6), 647–655. https://doi.org/10.1007/s00401008-0451-6 [CrossRef] [PubMed] [Google Scholar]
Eimer, W. A., & Vassar, R. (2013). Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation. Molecular Neurodegeneration, 8(1), 2. https://doi.org/10.1186/1750-1326-8-2 [CrossRef] [PubMed] [Google Scholar]
Fan, R., DeFilippis, K., & Van Nostrand, W. E. (2007). Induction of complement proteins in a mouse model for cerebral microvascular Aβ deposition. Journal of Neuroinflammation, 4(1), 22. https://doi.org/10.1186/1742-2094-4-22 [CrossRef] [PubMed] [Google Scholar]
Kern, E. R., Richards, J. T., Glasgow, L. A., Overall, J. C., & Miranda, D. (n.d.). Optimal Treatment of Herpes Simplex Virus Encephalitis in Mice with Oral Acyclovir. [Google Scholar]
Knopman, D. S., Haeberlein, S. B., Carrillo, M. C., Hendrix, J. A., Kerchner, G., Margolin, R., Maruff, P., Miller, D. S., Tong, G., Tome, M. B., Murray, M. E., Nelson, P. T., Sano, M., Mattsson, N., Sultzer, D. L., Montine, T. J., Jack, C. R., Kolb, H., Petersen, R. C., … Siemers, E. (2018). The National Institute on Aging and the Alzheimer’s Association Research Framework for Alzheimer’s disease: Perspectives from the Research Roundtable. Alzheimer’s & Dementia, 14(4), 563–575. https://doi.org/10.1016/j.jalz.2018.03.002 [CrossRef] [PubMed] [Google Scholar]
Lin, Y.-T., Seo, J., Gao, F., Feldman, H. M., Wen, H.L., Penney, J., Cam, H. P., Gjoneska, E., Raja, W. K., Cheng, J., Rueda, R., Kritskiy, O., Abdurrob, F., Peng, Z., Milo, B., Yu, C. J., Elmsaouri, S., Dey, D., Ko, T., … Tsai, L.-H. (2018). APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSCDerived Brain Cell Types. Neuron, 98(6), 1141-1154. e7. https://doi.org/10.1016/j.neuron.2018.05.008 [CrossRef] [PubMed] [Google Scholar]
Mancuso, R., Van Den Daele, J., Fattorelli, N., Wolfs, L., Balusu, S., Burton, O., Liston, A., Sierksma, A., Fourne, Y., Poovathingal, S., Arranz-Mendiguren, A., Sala Frigerio, C., Claes, C., Serneels, L., Theys, T., Perry, V. H., Verfaillie, C., Fiers, M., & De Strooper, B. (2019). Stem-cell-derived human microglia transplanted in mouse brain to study human disease. Nature Neuroscience, 22(12), 2111–2116. https://doi.org/10.1038/s41593-019-0525-x [CrossRef] [PubMed] [Google Scholar]
Martens, Y. A., Zhao, N., Liu, C.-C., Kanekiyo, T., Yang, A. J., Goate, A. M., Holtzman, D. M., & Bu, G. (2022). ApoE Cascade Hypothesis in the pathogenesis of Alzheimer’s disease and related dementias. Neuron, 110(8), 1304–1317. https://doi.org/10.1016/j.neuron.2022.03.004 [CrossRef] [PubMed] [Google Scholar]
Mendez, M. F. (2017). Early-Onset Alzheimer Disease. Neurologic Clinics, 35(2), 263–281. https://doi.org/10.1016/j.ncl.2017.01.005 [CrossRef] [PubMed] [Google Scholar]
Nabers, A., Perna, L., Lange, J., Mons, U., Schartner, J., Güldenhaupt, J., Saum, K., Janelidze, S., Holleczek, B., Rujescu, D., Hansson, O., Gerwert, K., & Brenner, H. (2018). Amyloid blood biomarker detects Alzheimer’s disease. EMBO Molecular Medicine, 10(5), e8763. https://doi.org/10.15252/emmm.201708763 [CrossRef] [PubMed] [Google Scholar]
Ortiz, G. C., Sheridan, J. F., & Marucha, P. T. (2003). Stress-induced changes in pathophysiology and interferon gene expression during primary HSV-1 infection. Brain, Behavior, and Immunity, 17(5), 329–338. https://doi.org/10.1016/S0889-1591(03)00027-8 [CrossRef] [PubMed] [Google Scholar]
Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F. T., & Arab-Tehrany, E. (2022). Alzheimer’s Disease: Treatment Strategies and Their Limitations. International Journal of Molecular Sciences, 23(22), 13954. https://doi.org/10.3390/ijms232213954 [CrossRef] [PubMed] [Google Scholar]
Piacentini, R., De Chiara, G., Li Puma, D. D., Ripoli, C., Marcocci, M. E., Garaci, E., Palamara, A. T., & Grassi, C. (2014). HSV-1 and Alzheimerâ€TMs disease: More than a hypothesis. Frontiers in Pharmacology, 5. https://doi.org/10.3389/fphar.2014.00097 [CrossRef] [PubMed] [Google Scholar]
Scheltens, P., De Strooper, B., Kivipelto, M., Holstege, H., Chételat, G., Teunissen, C. E., Cummings, J., & Van Der Flier, W. M. (2021). Alzheimer’s disease. The Lancet, 397(10284), 1577–1590. https://doi.org/10.1016/S0140-6736(20)32205-4 [CrossRef] [Google Scholar]
Serrano-Pozo, A., Das, S., & Hyman, B. T. (2021). APOE and Alzheimer’s disease: Advances in genetics, pathophysiology, and therapeutic approaches. The Lancet Neurology, 20(1), 68–80. https://doi.org/10.1016/S1474-4422(20)30412-9 [CrossRef] [PubMed] [Google Scholar]
Trybala, E., Bergström, T., Olofsson, S., Svennerholm, B., & Jeansson, S. (1995). An evaluation of a hemagglutination-inhibition test for the detection of antibodies to herpes simplex virus type 1. Clinical and Diagnostic Virology, 3(2), 191–201. https://doi.org/10.1016/0928-0197(94)00030-X [CrossRef] [PubMed] [Google Scholar]
Zheng, W., Benner, E. M., Bloom, D. C., Muralidaran, V., Caldwell, J. K., Prabhudesai, A., Piazza, P. A., Wood, J., Kinchington, P. R., Nimgaonkar, V. L., & D’Aiuto, L. (2022). Variations in Aspects of Neural Precursor Cell Neurogenesis in a Human Model of HSV-1 Infection. Organogenesis, 18(1), 2055354. https://doi.org/10.1080/15476278.2022.2055354 [CrossRef] [PubMed] [Google Scholar]

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