Open Access
| Issue |
BIO Web Conf.
Volume 209, 2026
The 1st International Conference on Biological Technology for Sustainable Nature (IC-BioTEStA 2025)
|
|
|---|---|---|
| Article Number | 02014 | |
| Number of page(s) | 9 | |
| Section | Biotechnology | |
| DOI | https://doi.org/10.1051/bioconf/202620902014 | |
| Published online | 09 January 2026 | |
- A. Hruby, F.B. Hu, The epidemiology of obesity: A big picture. Pharmacoeconomics 33, 673–689 (2015). https://doi.org/10.1007/s40273-014-0243-x [Google Scholar]
- G. Baldini, K.D. Phelan, The melanocortin pathway and control of appetite: progress and therapeutic implications. J. Endocrinol. 241, R1-R33 (2019). https://doi.org/10.1530/joe-18-0596 [Google Scholar]
- Z. Zheng, Y. Zong, Y. Ma, Y. Xu, X. Liu, F. Chen, C. Jiang, Q. Sun, Y. Hu, X. Gao, Q. Liu, H. Zhang, Glucagon-like peptide-1 receptor: mechanisms and advances in therapy. Sig. Transduct. Target Ther. 9, 234 (2024). https://doi.org/10.1038/s41392-024-01931-z [Google Scholar]
- H. Israeli, O. Degtjarik, M. Fierro, I. Nataf, A. Dessau, M. Ramon, A. Feinstein, M. Lerer, A. Oron, Y. Hirschberg, M. Scholle, N.A. Heyder, Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signalling. Science 372, 808–814 (2021). https://doi.org/10.1126/science.abf7958 [Google Scholar]
- J.P.H. Wilding, B. Batterham, J. Calanna, M. Rosenstock, S. Bolinder, L. Lingvay, S. Scheerer, M. Macias, A. Camps, G. Sandoval, O. Haddad, Once-weekly semaglutide in adults with overweight or obesity. N. Engl. J. Med. 384, 989–1002 (2021). https://doi.org/10.1056/NEJMoa2032183 [Google Scholar]
- I.J. Onakpoya, R. Posadzki, E. Ernst, The efficacy of Phaseolus vulgaris extract in reducing body weight: a systematic review and meta-analysis, Br. J. Nutr. 106, 196–202 (2011). https://doi.org/10.1017/s0007114511001516 [Google Scholar]
- D. Méndez-Luna, S. Guzmân-Velâzquez, I.I. Padilla-Martinez, J.R. Garcia-Sânchez, M. Bello, J.B. Garcia-Vâzquez, H.L. Mendoza-Figueroa, J. Correa-Basurto, GPER binding site detection and description: A flavonoid-based docking and molecular dynamics simulations study. J. Steroid Biochem. Mol. Biol. 239, 106474 (2024). https://doi.org/10.1016/i.isbmb.2024.106474 [Google Scholar]
- C.A. Lipinski, F. Lombardo, B.W. Dominy, P.J. Feeney, Experimental and computational approaches to estimate solubility and permeability in drug discovery. Adv. Drug Deliv. Rev. 46, 3–26 (2001). https://doi.org/10.1016/s0169-409x(00)00129-0 [Google Scholar]
- A. Daina, O. Michielin, V. Zoete, SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness. Sci. Rep. 7, 42717 (2017). https://doi.org/10.1038/srep42717 [CrossRef] [Google Scholar]
- D.E.V. Pires, T.L. Blundell, D.B. Ascher, pkCSM: Predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures. J. Med. Chem. 58, 4066–4072 (2015). https://doi.org/10.1021/acs.imedchem.5b00104 [Google Scholar]
- S. Forli, R. Huey, M.E. Pique, M.F. Sanner, D.S. Goodsell, A.J. Olson, Computational protein-ligand docking and virtual drug screening with the AutoDock suite. Nat. Protoc. 11, 905–919 (2016). https://doi.org/10.1038/nprot.2016.051 [Google Scholar]
- H. Zhang, A. Qiao, T. Yang, X. Yang, Q. Hao, J. Zhang, F. Bao, S. Khiari, L. Chen, J. Ma, Structure of the active melanocortin-4 receptor-Gs complex. Cell Res. 31, 460–463 (2021). https://doi.org/10.1038/s41422-021-00471-5 [Google Scholar]
- J.T. Ortega, T. Parmar, B. Jastrzebska, Flavonoids enhance rod opsin stability, folding, and self-association. J. Biol. Chem. 294, 6027–6042 (2019). https://doi.org/10.1074/ibc.RA119.007808 [Google Scholar]
- H. Ma, W. Huang, X. Wang, L. Zhao, Y. Jiang, F. Liu, W. Guo, X. Sun, W. Zhong, D. Yuan, H.E. Xu, Structural insights into the activation of GLP-1R by a small molecule agonist, Cell Res. 30, 1140–1142 (2020). https://doi.org/10.1038/s41422-020-0384-8 [Google Scholar]
- Y. Zhang, B. Sun, D. Feng, H. Hu, M. Chu, Q. Qu, J. Tarrasch, S. Li, B.K. Kobilka, Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature 546, 248–253 (2017). https://doi.org/10.1038/nature22394 [Google Scholar]
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.

