Evaluation of Kappaphycus striatus Lectin on SARS-CoV-2 Spike Protein-Specific IgG Responses

Open Access

Issue		BIO Web Conf. Volume 228, 2026 Biospectrum 2025: International Conference on Biotechnology and Biological Science


Article Number		02001
Number of page(s)		5
Section		Medical Biotechnology
DOI		https://doi.org/10.1051/bioconf/202622802001
Published online		11 March 2026

Y. Qin, Seaweed hydrocolloids as thickening, gelling, and emulsifying agents in functional food products, in Bioactive Seaweeds for Food Applications, pp. 135–152, (Academic Press, 2018). https://doi.org/10.1016/B978-0-12-813312-5.00007-8 [Google Scholar]
O.I. Şahin, Seaweed polysaccharides: structure, extraction and applications, in Polysaccharides, pp. 61–74, (John Wiley & Sons, 2021). https://doi.org/10.1002/9781119711414.ch4 [Google Scholar]
E.H. Teixeira, F.V.S. Arruda, K.S. do Nascimento, V.A. Carneiro, C.S. Nagano, B.R. da Silva, A.H. Sampaio and B.S. Cavada, Biological applications of plants and algae lectins: an overview, in Carbohydrates – Comprehensive Studies on Glycobiology and Glycotechnology, (InTech, 2012). https://doi.org/10.5772/50632 [Google Scholar]
E. Catanzaro, C. Calcabrini, A. Bishayee and C. Fimognari, Antitumor potential of marine and freshwater lectins. Mar. Drugs 18(1), 11 (2020). https://doi.org/10.3390/md18010011 [Google Scholar]
R.P. Chaves, S.R. da Silva, L.G.N. Neto, R.F. Carneiro, A.L.C. da Silva, A.H. Sampaio, B.L. de Sousa, M.G. Cabral, P.A. Videira, E.H. Teixeira and C.S. Nagano, Structural characterization of two isolectins from the marine red alga Solieria filiformis (Kützing) P.W. Gabrielson and their anticancer effect on MCF-7 breast cancer cells. Int. J. Biol. Macromol. 107, 1320–1329 (2018). https://doi.org/10.1016/j.ijbiomac.2017.09.116 [Google Scholar]
Y. Takebe, C.J. Saucedo, G. Lund, R. Uenishi, S. Hase, T. Tsuchiura, N. Kneteman, K. Ramessar, D.L.J. Tyrrell, M. Shirakura, T. Wakita, J.B. McMahon and B.R. O’Keefe, Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus. PLoS ONE 8(5), e64449 (2013). https://doi.org/10.1371/journal.pone.0064449 [Google Scholar]
I.M. Maliki, M. Misson, P.L. Teoh, K.F. Rodrigues, W.Y. Koh and W.T.L. Yong, Analysis of the binding specificity of N-acetylgalactosamine (GalNAc)-binding lectin isolated from Kappaphycus alvarezii to SARS-CoV-2 sugar moieties. Phycol. Res. 73(1), 8–16 (2025). https://doi.org/10.1111/pre.12570 [Google Scholar]
L.M. Field, W.R. Fagerberg, K.K. Gatto and S.A. Böttger, A comparison of protein extraction methods optimizing high protein yields from marine algae and cyanobacteria. J. Appl. Phycol. 29, 1271–1278 (2017). https://doi.org/10.1007/s10811-016-1027-9 [Google Scholar]
P.P. Sun, Y.Y. Ren, J. Zheng and A.J. Hu, Purification and characterization of a new lectin from loach skin mucus. J. Chem. 2019(1), 3853646 (2019). https://doi.org/10.1155/2019/3853646 [Google Scholar]
H.L. Dinh, K. Hori and N.H. Quang, Screening and preliminary characterization of hemagglutinins in Vietnamese marine algae. J. Appl. Phycol. 21, 89–97 (2009). https://doi.org/10.1007/s10811-008-9330-8 [Google Scholar]
B.W.S. Souza, F.K. Andrade, D.I.A. Teixeira, A. Mansilla and A.L.P. Freitas, Haemagglutinin of the Antarctic seaweed Georgiella confluens (Reinsch) Kylin: isolation and partial characterization. Polar Biol. 33, 1311–1318 (2010). https://doi.org/10.1007/s00300-010-0818-8 [Google Scholar]
K. Wørzner, D.J. Sheward, S.T. Schmidt, L. Hanke, J. Zimmermann, G. McInerney, G.B.K. Hedestam, B. Murrell, D. Christensen and G.K. Pedersen, Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice. EBioMedicine 63, 103197 (2021). https://doi.org/10.1016/j.ebiom.2020.103197 [Google Scholar]
M.E.P. Lima, M.E. Carneiro, A.E. Nascimento, T.B. Grangeiro, M.L. Holanda, R.C.N. Amorim and N.M.B. Benevides, Purification of a lectin from the marine red alga Gracilaria cornea and its effects on the cattle tick Boophilus microplus (Acari: Ixodidae). J. Agric. Food Chem. 53(16), 6414–6419 (2005). https://doi.org/10.1021/jf0509660 [Google Scholar]
F.R. Melo, N.M.B. Benevides, M.G. Pereira, M.L. Holanda, F.N.P. Mendes, S.R.M. Oliveira, A.L.P. Freitas and L.M.C.M. Silva, Purification and partial characterisation of a lectin from the red marine alga Vidalia obtusiloba C. Agardh. Braz. J. Bot. 27(2), 263–269 (2004). https://doi.org/10.1590/S0100-84042004000200006 [Google Scholar]
M.C. de Moraes, C.L. Cardoso and Q.B. Cass, Solid-supported proteins in the liquid chromatography domain to probe ligand–target interactions. Front. Chem. 7, 752 (2019). https://doi.org/10.3389/fchem.2019.00752 [Google Scholar]
D. Sudakevitz, A. Imberty and N. Gilboa-Garber, Production, properties and specificity of a new bacterial L-fucose- and D-arabinose-binding lectin of the plant aggressive pathogen Ralstonia solanacearum, and its comparison to related plant and microbial lectins. J. Biochem. 132(2), 353–358 (2002). https://doi.org/10.1093/oxfordjournals.jbchem.a003230 [Google Scholar]
J.W. Han, K.S. Yoon, T.A. Klochkova, M.-S. Hwang and G.H. Kim, Purification and characterization of a lectin, BPL-3, from the marine green alga Bryopsis plumosa. J. Appl. Phycol. 23, 745–753 (2011). https://doi.org/10.1007/s10811-010-9575-x [Google Scholar]
A. Barre, E.J.M. Van Damme, M. Simplicien, H. Benoist and P. Rougé, Man-specific, GalNAc/T/Tn-specific and Neu5Ac-specific seaweed lectins as glycan probes for SARS-CoV-2. Mar. Drugs 18(11), 543 (2020). https://doi.org/10.3390/md18110543 [Google Scholar]
F.A. Lempp, L.B. Soriaga, M. Montiel-Ruiz, F. Benigni, J. Noack, Y.-J. Park, S. Bianchi, A.C. Walls, J.E. Bowen, J. Zhou, H. Kaiser, A. Joshi, M. Agostini, M. Meury, E. Dellota Jr, S. Jaconi, E. Cameroni, J. Martinez-Picado, J. Vergara-Alert, N. Izquierdo-Useros, H.W. Virgin, A. Lanzavecchia, D. Veesler, L.A. Purcell, A. Telenti and D. Corti, Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies. Nature 598, 342–347 (2021). https://doi.org/10.1038/s41586-021-03925-1 [Google Scholar]

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