Open Access
Issue
BIO Web Conf.
Volume 233, 2026
9th International Conference on Advances in Biosciences and Biotechnology: Emerging Innovations in Biomedical and Bioengineering Sciences (ICABB 2026)
Article Number 01014
Number of page(s) 22
Section Biomedical and Health Innovations
DOI https://doi.org/10.1051/bioconf/202623301014
Published online 23 April 2026
  • AlZahrani, W. M., AlGhamdi, S. A., Zughaibi, T. A., & Rehan, M. (2022). Exploring the natural compounds in flavonoids for their potential inhibition of cancer therapeutic target MEK1 using computational methods. Pharmaceuticals, 15(2), 195. [Google Scholar]
  • Bahar, M. E., Kim, H. J., & Kim, D. R. (2023). Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies. Signal transduction and targeted therapy, 8(1), 455. [Google Scholar]
  • Banerjee, P., Eckert, A. O., Schrey, A. K., & Preissner, R. (2018). ProTox-II: a webserver for the prediction of toxicity of chemicals. Nucleic acids research, 46(W1), W257–W263. [Google Scholar]
  • Bashir, A., Asif, M., Saadullah, M., Saleem, M., Khalid, S. H., Hussain, L., ... & Chohan, T. A. (2022). Therapeutic potential of standardized extract of melilotus indicus (L.) all. and its phytochemicals against skin cancer in animal model: in vitro, in vivo, and in silico studies. ACS omega, 7(29), 25772–25782. [Google Scholar]
  • Bou-Dargham, M. J., Khamis, Z. I., Cognetta, A. B., & Sang, Q. X. A. (2017). The role ofinterleukin-1 in inflammatory and malignant human skin diseases and the rationale for targeting interleukin-1 alpha. Medicinal research reviews, 37(1), 180–216. [Google Scholar]
  • Bowers, K. J., Chow, D. E., Xu, H., Dror, R. O., Eastwood, M. P., Gregersen, B. A., Klepeis, J. L., Kolossvary, I., Moraes, M. A., Sacerdoti, F. D., & Shaw, D. E. (2006). Scalable algorithms for molecular dynamics simulations on commodity clusters. In Proceedings of the 2006 ACM/IEEE Conference on Supercomputing (p. 43). [Google Scholar]
  • Buyukkurt, O. K., Guclu, G., Kelebek, H., & Selli, S. (2019). Characterization of phenolic compounds in sweet lime (Citrus limetta) peel and freshly squeezed juices by LC-DAD ESI-MS/MS and their antioxidant activity. Journal of Food Measurement and Characterization, 13, 3242–3249. [Google Scholar]
  • Byun, E.B., Kim, H.M., Song, H.Y. and Kim, W.S., 2019. Hesperidin structurally modified by gamma irradiation induces apoptosis in murine melanoma B16BL6 cells and inhibits both subcutaneous tumor growth and metastasis in C57BL/6 mice. Food Chem. Toxicol. 127, 19–30. [Google Scholar]
  • Chauhan, P. (2018). Skin cancer and role of herbal medicines. Asian Journal of Pharmacy and Pharmacology, 4(4), 404–412. [Google Scholar]
  • Cheng, Y., & Tian, H. (2017). Current development status of MEK inhibitors. Molecules, 22(10), 1551–1571. [Google Scholar]
  • Chinembiri, T. N., Du Plessis, L. H., Gerber, M., Hamman, J. H., & Du Plessis, J. (2014). Review of natural compounds for potential Skin Cancer treatment. Molecules, 19(8), 11679–11721. [Google Scholar]
  • Choudhari, A. S., Mandave, P. C., Deshpande, M., Ranjekar, P., & Prakash, O. (2020). Phytochemicals in cancer treatment: From preclinical studies to clinical practice. Frontiers in pharmacology, 10, 1614. [Google Scholar]
  • Garlanda, C., & Mantovani, A. (2021). Interleukin-1 in tumor progression, therapy, and prevention. Cancer cell, 39(8), 1023–1027. [Google Scholar]
  • Garutti, M., Targato, G., Buriolla, S., Palmero, L., Minisini, A. M., & Puglisi, F. (2021). CDK4/6 inhibitors in melanoma: a comprehensive review. Cells, 10(6), 1334–1350. [Google Scholar]
  • Grimaldi, A. M., Simeone, E., Festino, L., Vanella, V., Strudel, M., & Ascierto, P. A. (2017). MEK inhibitors in the treatment of metastatic melanoma and solid tumors. American journal of clinical dermatology, 18(6), 745–754. [Google Scholar]
  • Guo, L., Qi, J., Wang, H., Jiang, X., & Liu, Y. (2020). Getting under the skin: The role of CDK4/6 in melanomas. European Journal of Medicinal Chemistry, 204, 112531. [Google Scholar]
  • Hamilton, E., & Infante, J. R. (2016). Targeting CDK4/6 in patients with cancer. Cancer treatment reviews, 45, 129138. [Google Scholar]
  • Hassan, M. H. (2021). In vitro and in vivo Study of Banana Peel Extract Anti Toxicity. Medico-legal Update, 21(2). [Google Scholar]
  • Kaloni, D., Chakraborty, D., Tiwari, A., & Biswas, S. (2020). In silico studies on the phytochemical components of Murraya koenigii targeting TNF-a in rheumatoid arthritis. Journal of Herbal Medicine, 24, 100396. [Google Scholar]
  • Kandeel, M., Iqbal, M. N., Ali, I., Malik, S., Malik, A., & Sehgal, S. A. (2023). Comprehensive in silico analyses of flavonoids elucidating the drug properties against kidney disease by targeting AIM2. Plos one, 18(5), e0285965. [Google Scholar]
  • Keta, O. D., Deljanin, M., Petkovic, V., Zdunic, G., Jankovic, T., Zivkovic, J., ... & Savikin, K. (2020). Pomegranate (Punica granatum L.) Peel Extract: potential cytotoxic agent against different cancer cell lines. Records of Natural Products, 14(5), 326–339. [Google Scholar]
  • Khan, A. A., Mahmood, T., Siddiqui, H. H., & Akhtar, J. (2016). Phytochemical and pharmacological properties on C. limetta (Mosambi). Journal of Chemical and Pharmaceutical Research, 8(3), 555–563. [Google Scholar]
  • Lolok, N., Sumiwi, S. A., Muhtadi, A., Susilawati, Y., Hendriani, R., Ramadhan, D. S. F., ... & Sahidin, I. (2022). Molecular docking and molecular dynamics studies of bioactive compounds contained in noni fruit (Morinda citrifolia L.) against human pancreatic a-amylase. Journal of Biomolecular Structure and Dynamics, 40(15), 70917098. [Google Scholar]
  • Malcova, H., Strizova, Z., Milota, T., Striz, I., Sediva, A., Cebecauerova, D. et al. (2021). IL-1 inhibitors in the treatment of monogenic periodic fever syndromes: from the past to the future perspectives. Frontiers in Immunology, 11, 619257. [Google Scholar]
  • Maulydia, N. B., Tallei, T. E., Ginting, B., Idroes, R., & Faradilla, M. (2022). Analysis of flavonoid compounds of Orange (Citrus sp.) peel as anti-main protease of SARS-CoV-2: A molecular docking study. IOP Conference Series: Earth and Environmental Science, 951(1), 012078. [Google Scholar]
  • Maurya, A. K., Mohanty, S., Pal, A., Chanotiya, C. S., & Bawankule, D. U. (2018). The essential oil from C. limetta Risso peels alleviates skin inflammation: In-vitro and in-vivo study. Journal of ethnopharmacology, 212, 86–94. [Google Scholar]
  • Mendie, L. E., & Hemalatha, S. (2022). Molecular docking of phytochemicals targeting GFRs as therapeutic sites for cancer: an in silico study. Applied biochemistry and biotechnology, 194(1), 215–231. [Google Scholar]
  • Noor, H., Ikram, A., Rathinavel, T., Kumarasamy, S., Nasir Iqbal, M., & Bashir, Z. (2022). Immunomodulatory and anti-cytokine therapeutic potential of curcumin and its derivatives for treating COVID-19 - a computational modeling. Journal of Biomolecular Structure and Dynamics, 40(13), 5769–5784. [Google Scholar]
  • Qi, J., & Ouyang, Z. (2022). Targeting CDK4/6 for anticancer therapy. Biomedicines, 10(3), 685. [Google Scholar]
  • Rasool, S., Ahmed, H., Uttra, M. M., Uttra, A. M., Khan, M. R., Zakir, K. A., ... & Saleem, F. (2021). Antioxidant and anti-cancer effect of ethanolic extract of citrus fruits on Hep G2 and MCF-7 cell lines. Journal of Pharmaceutical Research International, 33(49A), 84–90. [Google Scholar]
  • Rolta, R., Yadav, R., Salaria, D., Trivedi, S., Imran, M., Sourirajan, A., ... & Dev, K. (2021). In silico screening of hundred phytocompounds of ten medicinal plants as potential inhibitors of nucleocapsid phosphoprotein of COVID- 19. Journal of Biomolecular Structure and Dynamics, 39(18), 7017–7034. [Google Scholar]
  • Sakshi, C., Harikrishnan, A., Jayaraman, S., Choudhury, A. R., & Veena, V. (2022). Predictive medicinal metabolites from Momordica dioica against comorbidity related proteins of SARS-CoV-2 infections. Journal of Biomolecular Structure and Dynamics, 40(11), 5175–5188. [Google Scholar]
  • Samarasinghe, V., & Madan, V. (2012). Nonmelanoma Skin Cancer. Journal of Cutaneous and Aesthetic Surgery, 5(1), 3–10. [Google Scholar]
  • Seifabadi, S., Vaseghi, G., Ghannadian, M., & Javanmard, S. H. (2019). Standardized Punica Granatum pericarp extract, suppresses tumor proliferation and angiogenesis in a mouse model of melanoma: possible involvement of PPARa and PPARY pathways. Iranian journal of pharmaceutical research: IJPR, 18(1), 348. [Google Scholar]
  • Sever, R., & Brugge, J. S. (2015). Signal transduction in cancer. Cold Spring Harbor perspectives in medicine, 5(4), a006098. [Google Scholar]
  • Shi, C. J., Xu, S. M., Han, Y., Zhou, R., & Zhang, Z. Y. (2021). Targeting cyclin-dependent kinase 4/6 as a therapeutic approach for mucosal melanoma. Melanoma Research, 31(6). [Google Scholar]
  • Shyam, J. (2019). The Phytochemical and Pharmacological Activity of C. limetta Peel Extracts. Journal of Global Biosciences, 8(8), 6382–6396. [Google Scholar]
  • Thirumalaisamy, R., Aroulmoji, V., Iqbal, M. N., Saride, S., Bhuvaneswari, M., Deepa, M., ... & Khan, R. (2023). Molecular insights of hyaluronic acid-ethambutol and hyaluronic acid-isoniazid drug conjugates act as promising novel drugs for the treatment of tuberculosis. Journal of Biomolecular Structure and Dynamics, 41(8), 3562–3573. [Google Scholar]
  • Unsworth, A. J., Bye, A. P., Kriek, N., Sage, T., Osborne, A. A. et al. (2019). Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction. Platelets, 30(6), 762–772. [Google Scholar]
  • Wander, S. A., O'Brien, N., Litchfield, L. M., O'Dea, D., Morato Guimaraes, C. et al. (2022). Targeting CDK4 and 6 in cancer therapy: emerging preclinical insights related to abemaciclib. The oncologist, 27(10), 811–821. [Google Scholar]
  • Wang, F., Chen, J., Xiang, D., Lian, X., Wu, C., & Quan, J. (2020). Ellagic acid inhibits cell proliferation, migration, and invasion in melanoma via EGFR pathway. American Journal of Translational Research, 12(5), 2295. [Google Scholar]
  • Yousuf, M., Khan, P., Shamsi, A., Shahbaaz, M., Hasan, G. M., et al. (2020). Inhibiting CDK6 activity by quercetin is an attractive strategy for cancer therapy. ACS omega, 5(42), 27480–27491. [Google Scholar]
  • Zhang, X.M., Chen, J., Xia, Y.G. and Xu, Q. (2005). Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-a and translocating PKC-5. Cancer Chemotherapy and Pharmacology. 55(3), 251–262. [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.