BIO Web Conf.
Volume 8, 20172016 International Conference on Medicine Sciences and Bioengineering (ICMSB2016)
|Number of page(s)||5|
|Section||Session I: Medicine|
|Published online||11 January 2017|
Reduced gray matter volume of left superior temporal gyrus in schizophrenia with auditory verbal hallucinations: a voxel-based morphometry study
1 Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 625014, China
2 The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, 510370, China
a Correspondence Author: firstname.lastname@example.org
Auditory verbal hallucinations (AVHs) which are the core psychopathology symptoms in schizophrenia patients cause amounts of distress, functional disability and behavioral dys-control. However, the neural mechanism with the onset of AVHs in schizophrenia remains unclear. In the present study, we recruited 30 schizophrenia patients with AVHs, 20 schizophrenia patients with non-AVHs (nAVHs), and 50 healthy controls. Structure magnetic resonance imaging was obtained, and voxel-based morphometry (VBM) was used to analyse the gray matter volume (GMV) in the three groups. We found that the GMV of anterior cingulate cortex (ACC), left superior temporal gyrus (STG), and left middle temporal gyrus (MTG) significantly decreased in schizophrenia patients compared to healthy controls. In addition, the left STG with significantly decreased volume was found in nAVHs compared to AVHs, but no significant changes of GMV in ACC and left MTG were found between AVHs and nAVHs. Our current study identified the abnormal GMV of the left STG in schizophrenia patients with AVHs. Our findings further supported the view that, whilst mild reduced GMV of the left STG might still enable the emergence of AVHs, more severe alterations may prevent the occurrence of AVHs experience.
© The Authors, published by EDP Sciences, 2017
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