The clinical value of HbA1c in combination with FPG in the early screening of the elderly with type 2 diabetes

¹ Department of Biochemistry and Molecular Biology, Gannan Medical College, Ganzhou, Jiangxi, China
² Department of Anesthesiology GanZhou Municipal Hospital, Ganzhou Jiangxi, China
³ Department of Epidemiology in Preventive Medicine, Gannan Medical College, Ganzhou, Jiangxi, China
⁴ Department of Clinical laboratory of 1’th affiliate hospital, Gannan Medical College, Ganzhou, Jiangxi, China
⁵ Department of Anatomy Gannan Medical College, Ganzhou, Jiangxi, China

^a Corresponding author: Shumei Li, gnyxylsm@163.com Phone: 008615083787928.
^# These authors contributed equally to this study and share first authorship.

Abstract

Objective: To investigate the FPG associated with HbA1c diagnosis of T2DM, to clear the best point of tangency HbA1c diagnosis of T2DM. Methods: Using simple random sampling method, from this group of T2DM field epidemiological investigation data in the database we randomly selected 300 cases of T2DM patients, 300 cases of healthy people. The sensitivity and specificity of FPG, HbA1c and HbA1c/FPG combination were calculated by diagnostic screening test; Using ROC curve evaluation FPG, HbA1c and HbA1c in combination with FPG diagnosis value of T2DM. Results: The cutoff point of FPG for diagnosing T2DM was 6.19 mmol/L, the sensitivity and specificity were respectively: 83.00%, 93.67%, area under the curve (AUC) was 0.928; the cutoff point of HbA1c for diagnosing T2DM was 6.40%, the sensitivity and specificity were respectively: 87.00%, 90.33%, area under the curve (AUC) is 0.935;Combined use of HbA1c and FPG in the diagnosis of T2DM, simultaneous detection of HbA1c and FPG, when HbA1c≥ 6.40% or FPG≥6.19 mmol/L diagnosed with T2DM, the sensitivity and specificity were respectively: 97.79%, 84.61%, area under the curve (AUC) is 0.960. Conclusions: The cutoff point of HbA1c for diagnosing T2DM was 6.40% , Combined HbA1c and FPG in the T2DM diagnosis, which can greatly improve the sensitivity, the combined application is more conducive to the early screening of T2DM.