BIO Web Conf.
Volume 8, 20172016 International Conference on Medicine Sciences and Bioengineering (ICMSB2016)
|Number of page(s)||4|
|Section||Session II: Bioinformatics|
|Published online||11 January 2017|
Effect of Cornus officinalis glycosides on the myelin basic protein in blood serum and the nerve function in Balb/c mice after sciatic nerve injury
1 China–Japan Union Hospital of Jilin University
2 The 4 th Hospital of Jilin University(The General Hospital of FAW)
a Corresponding author: email@example.com
Objective: to explore the effect of cornus officinalis glycosides(COG) on the myelin basic protein(MBP) in blood serum andthe nerve function in Balb/c mice after sciatic nerve injury. Methods : Adult male Balb/c mice were randomly divided into high-dose, middle-dose, low-dose COG groups,.Transecting and inosculating the right sciatic nerve; testing the concentration of MBP by ELISA in 3, 5 days, 1, 2, 4, 8 weeks and having electroneurophysiological detection in 4, 8 and 12 weeks after surgery respectively; making statistical analysis of the results. Results: The MBP concentration and results of lectroneurophysiological detection have clear dose-effect relationship with the COG dose. Conclusion: Through inhibiting the demyelination of the sciatic nerve , COG can lower the degree of nerve damage so that accelerating the nerve regeneration.
© The Authors, published by EDP Sciences, 2017
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.