BIO Web Conf.
Volume 8, 20172016 International Conference on Medicine Sciences and Bioengineering (ICMSB2016)
|Number of page(s)||4|
|Section||Session II: Bioinformatics|
|Published online||11 January 2017|
Effect of Cornus officinalis glycosides on the myelin basic protein in blood serum and the nerve function in Balb/c mice after sciatic nerve injury
1 China–Japan Union Hospital of Jilin University
2 The 4 th Hospital of Jilin University(The General Hospital of FAW)
a Corresponding author: firstname.lastname@example.org
Objective: to explore the effect of cornus officinalis glycosides(COG) on the myelin basic protein(MBP) in blood serum andthe nerve function in Balb/c mice after sciatic nerve injury. Methods : Adult male Balb/c mice were randomly divided into high-dose, middle-dose, low-dose COG groups,.Transecting and inosculating the right sciatic nerve; testing the concentration of MBP by ELISA in 3, 5 days, 1, 2, 4, 8 weeks and having electroneurophysiological detection in 4, 8 and 12 weeks after surgery respectively; making statistical analysis of the results. Results: The MBP concentration and results of lectroneurophysiological detection have clear dose-effect relationship with the COG dose. Conclusion: Through inhibiting the demyelination of the sciatic nerve , COG can lower the degree of nerve damage so that accelerating the nerve regeneration.
© The Authors, published by EDP Sciences, 2017
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