Case studies in brain dosimetry for internal emitters: Is more detail needed for epidemiology?

¹ Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
² U.S. Transuranium and Uranium Registries, College of Pharmacy, Washington State University, 1845 Terminal Drive, Suite 201, Richland, WA 99354, USA
³ National Council on Radiation Protection and Measurements, 7910 Woodmont Ave, Ste 400, Bethesda, MD 20814, USA

^* Corresponding author: leggettrw@ornl.gov

Abstract

Element-specific biokinetic models are used to reconstruct doses to systemic tissues from internal emitters. These models typically depict explicitly only those tissues that tend to dominate the systemic behaviour of the element over time. The remaining tissues are aggregated into a pool called Other tissue in which activity is assumed to be uniformly distributed. Explicitly identified tissues usually consist of some subset of the tissues liver, kidneys, bone, bone marrow, gonads, thyroid, spleen, and skin.