BIO Web Conf.
Volume 14, 2019The 12th International Conference on the Health Effects of Incorporated Radionuclides (HEIR 2018)
|Number of page(s)||2|
|Section||Medical Coutermeasures and Decorporation: Poster presentation|
|Published online||07 May 2019|
Impact of repeated dose of stable iodine in an in utero rat model using a metabolomic approach
Aix Marseille Univ, INSERM, INRA, C2VN, Marseille, France
2 Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, 92260 Fontenay-aux-Roses, France
The Fukushima nuclear power plant blast resulted in the release of 131Iodine for several weeks. This unexpected issue challenged the iodin doctrine , in which the counter-measure is to provide a unique iodine tablet to saturate thyroid during the radioactive contamination not expected to last more than several hours. A new doctrine must be implemented to take into account such case of extended exposure based on repeated iodine administration with adapted dosage. But repeated administration of iodine can block the thyroid  and few scientific evidences regarding repeated iodine administration (and its potential undesirable effect) are at our disposal . Moreover, unborn and young children are at high risk during a nuclear incident: it is currently recognized that one of the risks of exposure to radioactive iodine is the development of thyroid cancer, especially when exposure occurred during childhood . Their protection is a main priority. Our goal was to evaluate the potential undesirable effects of such repeated iodine administration in the offspring using an untargeted metabolomic approach on a rat reproductive model.
© The Authors, published by EDP Sciences, 2019
This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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