Open Access
Issue
BIO Web Conf.
Volume 14, 2019
The 12th International Conference on the Health Effects of Incorporated Radionuclides (HEIR 2018)
Article Number 06007
Number of page(s) 2
Section Medical Coutermeasures and Decorporation: Poster presentation
DOI https://doi.org/10.1051/bioconf/20191406007
Published online 07 May 2019

© The Authors, published by EDP Sciences, 2019

Licence Creative Commons
This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Pregnant rats received repeated doses of potassium iodine (KI group: 1mg/kg/24h) or water for injection (control group) for 8 days. The potential metabolic disruption was investigated in the offspring 30 days after weaning.

Using LC-MS, we compared the blood’s metabolite composition between KI and control male rats; using a high throughput annotation procedure with an in-house databank, 264 metabolites were annotated (based on retention time and exact mass), combined in 52 functional biological modules/pathways, and converted into corresponding scores using a PLS multiblock algorithm (see Fig. 1).

thumbnail Fig. 1

Hierarchical PLS-DA based on 51 functional biological modules, CV-ANOVA p-value = 0.0018

Running a random forests test, we found 19 modules significantly impacted by the KI treatment (VIP values > 0.05) including pathways of redox status, aminoacids, TCA cycle or oxidative stress. These findings indicated a prenatal effect of KI administration that lasted over the long term (adolescence). Whether or not these outcomes are pathological is unknown.

References

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All Figures

thumbnail Fig. 1

Hierarchical PLS-DA based on 51 functional biological modules, CV-ANOVA p-value = 0.0018

In the text

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