Open Access
BIO Web Conf.
Volume 14, 2019
The 12th International Conference on the Health Effects of Incorporated Radionuclides (HEIR 2018)
Article Number 06007
Number of page(s) 2
Section Medical Coutermeasures and Decorporation: Poster presentation
Published online 07 May 2019

© The Authors, published by EDP Sciences, 2019

Licence Creative CommonsThis is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Pregnant rats received repeated doses of potassium iodine (KI group: 1mg/kg/24h) or water for injection (control group) for 8 days. The potential metabolic disruption was investigated in the offspring 30 days after weaning.

Using LC-MS, we compared the blood’s metabolite composition between KI and control male rats; using a high throughput annotation procedure with an in-house databank, 264 metabolites were annotated (based on retention time and exact mass), combined in 52 functional biological modules/pathways, and converted into corresponding scores using a PLS multiblock algorithm (see Fig. 1).

thumbnail Fig. 1

Hierarchical PLS-DA based on 51 functional biological modules, CV-ANOVA p-value = 0.0018

Running a random forests test, we found 19 modules significantly impacted by the KI treatment (VIP values > 0.05) including pathways of redox status, aminoacids, TCA cycle or oxidative stress. These findings indicated a prenatal effect of KI administration that lasted over the long term (adolescence). Whether or not these outcomes are pathological is unknown.


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All Figures

thumbnail Fig. 1

Hierarchical PLS-DA based on 51 functional biological modules, CV-ANOVA p-value = 0.0018

In the text

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