Study of comparative antiparasitic efficacy of C-18 compound in cattle nematodirosis and eymeriosis

Kazan State Academy of Veterinary Medicine named after N.E. Bauman, 420029 Kazan, Russia

^* Corresponding author: parasitology-kazan@mail.ru

Abstract

The comparative antiparasitic efficacy of the compound “C-18, “ tetramisol granutate, albendazole, diacox, and toltarox in nematodirosis and eymeriosis of cattle has been studied. Studies were carried out on forty calves of 6 months of age naturally infected with nematodiruses and on the same number of animals invaded by eimerias. The preparations were administered individually by mouth. The first group of calves was given a 1% introduction solution of 10% tetramisol granulate, the second group a 10% suspension of albendazole. The preparations were given according to the guidelines for their use. Animals in the third group received a 1% solution of C-18 on sunflower oil at a dose of 2 mg/kg. Group four served as controls. Fecal samples were taken and examined before as well as 7, 15 and 30 days after administration of the preparations. 30 days after dehelmintisation, the intencity and extensity of efficacy of the C-18 compound was found to be 95.0 and 90.0%, versus 82.9 and 60.0% for tetramisol granulate and 90.4 and 80.0% for albendazole. Studies have shown that in cattle nematodirosis, the compound “C-18” is more effective than the known preparations tetramisol granulate and albendazole. A similar pattern is established in the examination of animal feces samples 7 and 15 days after deworming. In the second series of experiments, animals of the first group naturally infected with eimerias were fed diacox by group method at a dose of 1.0 mg/kg, the second 10% toltarox suspension was administered individually orally at a dose of 0.3 ml/kg, the third 1% solution of compound “C-18” on salt oil individually orally at a dose of 2.0 mg/kg. Studies have shown that in the case of eymeriosis of cattle, intensity of efficacy in diacox 15 days after treatment was 84.0, toltarox 88.9, and compounds “C-18” 88.6%, extensity of efficacy 50.0 and 83.3%, respectively.