| Issue |
BIO Web Conf.
Volume 17, 2020
International Scientific-Practical Conference “Agriculture and Food Security: Technology, Innovation, Markets, Human Resources” (FIES 2019)
|
|
|---|---|---|
| Article Number | 00195 | |
| Number of page(s) | 4 | |
| DOI | https://doi.org/10.1051/bioconf/20201700195 | |
| Published online | 28 February 2020 | |
Correlation of glutathione reductase activity distribution in the blood serum and tissues of white unborn rats
1
Kazan State Academy of Veterinary Medicine named after N.E. Bauman, Kazan 420029, Russia
2
Reaviz Medical University, editorial office, Samara 443001, Russia
3
TestGen LLC, Ulyanovsk 432072, Russia
* Corresponding author: casiopeya13@mail.ru
It is known that the majority of pathological processes take place against the background of formation of active oxygen species and intensification of free radical oxidation of bio-substrates. In response to this, the antioxidant system of the cell is activated, and the glutathione system is an important link in this system. The latter can take part in the maintenance of the optimal state of biomembranes, in the processes of detoxification, antioxidant protection, etc. The biological role of glutathione reductase is to maintain high intracellular concentration of reduced glutathione. The aim of our study was to study the relationship between the distribution of glutathione reductase activity in blood serum and rat tissues. In order to achieve the goal of the study the following tasks were solved: the activity of glutathione reductase in blood serum and tissues of liver, brain, heart, as well as in skeletal muscle tissues of rats was determined; the interrelation of the activity distribution of glutathione reductase in blood serum and tissues of rats was revealed. The article presents the results of nonparametric correlation analysis to assess the relationship between the distribution of glutathione reductase activity in blood serum and tissues of small experimental animals.
© The Authors, published by EDP Sciences, 2020
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