The role of light desynchronosis in the development of stress-induced aging

¹ Federal State Budgetary Institution of Science “Institute of Toxicology of the Federal Medical and Biological Agency”. 192019, Bekhtereva Str., 1, Saint Petersburg, Russian Federation
² Saint Petersburg State Pediatric Medical University, 194100, Litovskaya Str., 2, Saint Petersburg, Russian Federation

^* Corresponding author: bkaterina2009@yandex.ru

Abstract

The long-term change of the light mode for three months – light desynchronosis, disturbs the rhythm of the signals received from the external pacemaker. As a result of the study, it was found that a long-term change in the light mode and a violation of the rhythmicity of signals received from an external pacemaker contributes to the activation of ROS formation as triggers for bioenergetic processes in the cell. At the same time, changing the light mode disrupts the balance of oxygen in the cell and this is a provoking factor for the stress of the antioxidant cell system. The resulting tissue hypoxia in chronic light desynchronosis disrupts the bioenergetic potential of the cell, contributing to the development of pathophysiological processes and the death of neurons. Therefore, a violation of the balance of the pro-oxidant and anti-oxidant systems leads to destructive processes in the brain. A significant change in the concentration of the neurotrohic markers indicates destructive processes in the brain tissues. Summarizing the above, we conclude that light desynchronosis is directly involved in the ROS-dependent stress-induced aging of brain cells and in that way, to the progression of processes that lead to aging of the body.