| Issue |
BIO Web Conf.
Volume 22, 2020
International Conference “Longevity Interventions 2020” (ICLI 2020)
|
|
|---|---|---|
| Article Number | 02015 | |
| Number of page(s) | 7 | |
| Section | Actual Problems of Medicine | |
| DOI | https://doi.org/10.1051/bioconf/20202202015 | |
| Published online | 06 July 2020 | |
Obtaining hepatocytes by transdifferentiation of multipotent mesenchymal stromal cells by genetic engineering
1
Ural State Medical University, 620028, Repin Str., 3, Ekaterinburg, Russian Federation
2
Institute of Medical Cell Technology, 620026, Ekaterinburg, Russian Federation
3
Ural Federal University, 620002, Mira Str., 19, Ekaterinburg, Russian Federation
Therapy of liver failure is a common and insufficiently resolved problem. One of the options for its solution it is a liver transplantation. However, this method has a number of drawbacks, which include a limited number of donors and transplant rejection. The use of autologous hepatocytes would allow significant progress to solve the problem under discussion. The work considers a method that allowed obtaining autologous hepatocytes by transdifferentiation of multipotent mesenchymal stromal cells using genetic engineering methods.
© The Authors, published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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