Development of a bioaction complex for the onychodystrophy treatment

¹ Ural state medical university, Department of Dermatovenereology and Life Safety, 620028, Repin Str., 3, Yekaterinburg, Russian Federation
² Ural state medical university, Department of Pharmacy and Chemistry, 620028, 3, Repin Str., Yekaterinburg, Russian Federation

Abstract

This article is devoted to the problem of onychodystrophy treatment. The purpose of the study was to develop a bioactive complex for the external treatment of onychodystrophies. We conducted a prospective cohort study to determine the emotional status and life quality of patients with onychodystrophies. The optimal composition and technology for producing a complex for the onychodystrophy treatment was determined in vitro. We made a literature review using the PubMed, eLibrary, Scopus, Web of Science search engines. The structure of onychodystrophies in patients of the study group was determined, clinical forms such as leukonychia, paronychia, onycholysis were diagnosed the most frequently. A significant decrease in life quality was found in 86.8% of patients. A new method of onychodystrophies treatment using the innovative medical complex, which includes an emulsion for external use and camouflage nail polish is proposed. The developed bioactive complex for patients with onychodystrophy will contribute to the rapid regeneration of the changed nail plate due to improved microcirculation and trophic innervation. More viscous and thick consistency physiological colour nail polish which does not require polymerization, will create a visual effect of a healthy nail plate, which will improve the life quality of patients with onychodystrophy.