BIO Web Conf.
Volume 59, 20232023 5th International Conference on Biotechnology and Biomedicine (ICBB 2023)
|Number of page(s)||4|
|Section||Precision Medicine and Drug Development and Preparation|
|Published online||08 May 2023|
Pharmacokinetic prediction of nebulised polymyxin for pulmonary delivery
a School of Energy and Environment, Southeast University, Nanjing, 210096, China
b Department of Chemical Engineering, Monash University, Clayton, Vic 3800, Australia
* Corresponding author. Tel: +86 186-2500-1504; Email: email@example.com
Inhaled administration of polymyxin B is increasingly used to treat multi-drug resistant bacterial lung infections. However, the lack of clinical data on the pharmacokinetics of inhaled administration makes drug dose design, efficacy assessment and drug safety assessment a challenge. In this study, clinical data from intravenous injections were deconvoluted by an equal-step numerical deconvolution algorithm to derive the drug absorption rate of polymyxin B in vivo. The absorption rate was substituted into a published pulmonary absorption compartment model to predict the systemic pharmacokinetics of polymyxin B. It was demonstrated that the intravenous PK dataset with the pulmonary compartment model provided reliable estimates of the accuracy and bias of inhaled systemic pharmacokinetics.
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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