| Issue |
BIO Web Conf.
Volume 59, 2023
2023 5th International Conference on Biotechnology and Biomedicine (ICBB 2023)
|
|
|---|---|---|
| Article Number | 02016 | |
| Number of page(s) | 7 | |
| Section | Precision Medicine and Drug Development and Preparation | |
| DOI | https://doi.org/10.1051/bioconf/20235902016 | |
| Published online | 08 May 2023 | |
Optimization of Preparation Process and Pharmacokinetics of APAP Double-Release Pellet Capsules
1 Chemical Engineering Institute, Qingdao University of Science and Technology, Qingdao, China
2 Department of Medicine, Jinzhou Medical University, Jinzhou, China
3 Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, China
a 1547357926@qq.com
b 930520491@qq.com
c 1592974052@qq.com
d 1716488452@qq.com
e 1533046170@qq.com
f* Corresponding author 18253809808@163.com
In order to develop a kind of APAP double-release pellet capsules, which was prepared with the manual filling method, the immediate and sustained release pellets of a certain proportion were prepared by the fluidized bed coating and the extrusion spheroidization process, respectively. It was founded that both the prepared immediate-release pellets and sustained-release pellets had smooth and round surfaces. The particle size distribution ranged evenly from 16 to 35 mesh. Response surface plots showed that the optimal preparation prescription for immediate-release pellets were that ethanol concentration (X1) 70%, APAP 20%, MCC (X2) 40%, PVP K30 (X3) 20%, and sucrose pellet core 20%; and the optimal preparation prescription for sustained-release pellets were that HPMC concentration (X*3) 6.5%, APAP 30%, EC (X*1) 20%, MCC (X*2) 40%, PVP K30 4%, and lactose 6%. The results of pharmacokinetic analysis revealed that, after the APAP double-release pellet was orally administered, compared with that of conventional tablets, the plasma APAP levels in the blood circulation dramatically rose to significant peaks as a result of the quick and slow release of APAP from the capsules, which significantly prolonged the effective time of drugs in blood. Finally, immediate and sustained antipyretic-analgesic effects were obtained.
© The Authors, published by EDP Sciences, 2023
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