| Issue |
BIO Web Conf.
Volume 60, 2023
2022 4th International Conference on Biotechnology and Food Science (BFS 2022)
|
|
|---|---|---|
| Article Number | 02020 | |
| Number of page(s) | 5 | |
| Section | Agricultural Biotechnology and Food Safety | |
| DOI | https://doi.org/10.1051/bioconf/20236002020 | |
| Published online | 11 May 2023 | |
Risperidone Powder Prepared by Spray Drying Technology for Intranasal Delivery
1 Center for Simulation and Modeling of Particulate Systems, Southeast University-Monash University Joint Research Institute, Suzhou, Jiangsu, PR China
2 Department of Chemical Engineering Monash University Clayton, Vic, Australia
a email: 1106810853@qq.com
b email: 2116451422@qq.com
* Corresponding author: e-mail: z.tong@seu.edu.cn
The main objective of this study was to prepare Risperidone (RIS) nasal powder by spray drying method, so as to achieve controlled drug release and high deposition efficiency in the nasal cavity. The microparticles with uniform size and controllable structure were prepared by mixing hydroxypropyl -βcyclodextrin (CD) with API before a novel microfluidic spray drying technology. The properties of particles were characterized in terms of particle size, crystal shape and in vitro local deposition efficiency, and the formation mechanism and structure-activity relationship of particles were revealed. The results showed that the spray drying samples were all in amorphous state, and the physicochemical properties of risperidone can be improved by the addition of CD. Compared to spray-dried pure RIS, spray-dried samples with CD addition had good fluidity (CI<30%) and more suitable particle sizes (35-55μm) for nasal delivery. When the mass ratio of drug excipients (RIS: CD) was 1:6, the deposition fraction in the olfactory region was 13.338%, indicating that this prescription has considerable potential for brain targeted delivery.
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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