| Issue |
BIO Web Conf.
Volume 61, 2023
6th International Conference on Frontiers of Biological Sciences and Engineering (FBSE 2023)
|
|
|---|---|---|
| Article Number | 01006 | |
| Number of page(s) | 18 | |
| DOI | https://doi.org/10.1051/bioconf/20236101006 | |
| Published online | 21 June 2023 | |
Advances in GLP-1 receptor agonists for the treatment of type 2 diabetes
State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China
* Corresponding author: 2020141660015@stu.scu.edu.cn
Glucagon-like peptide-1 (GLP-1), an incretin secreted by intestinal L cells, has become a critical target for the treatment of type 2 diabetes because of its physiological effects of augmenting insulin secretion, suppressing glucagon secretion, and decelerating gastric emptying. Human endogenous GLP-1 is found to be proteolytically degraded and inactivated by DPP-4, which considerably limits the therapeutic effects of GLP-1. In contrast, GLP-1RAs undergo significant improvement in drug stability. In this context, several successful strategies for the development of GLP-1RAs and the corresponding problems are fully elaborated. The assay gives a brief overview of the pharmacological effects, advantages and common adverse effects of GLP-1RAs, shedding light on the latest research progress of GLP-1RAs, including new dosage forms, new drug targets and new clinical applications.
© The Authors, published by EDP Sciences, 2023
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