| Issue |
BIO Web Conf.
Volume 65, 2023
EBWFF 2023 - International Scientific Conference Ecological and Biological Well-Being of Flora and Fauna (Part 2)
|
|
|---|---|---|
| Article Number | 05001 | |
| Number of page(s) | 8 | |
| Section | Preventive Healthcare and Urban Ecology | |
| DOI | https://doi.org/10.1051/bioconf/20236505001 | |
| Published online | 04 September 2023 | |
Transformation of primary myelofibrosis into acute myeloblastic leukemia: clinical case
Astana Medical University NJSC, 010000 Astana, Kazakhstan
* Corresponding author: kir.kareev@mail.ru
Primary myelofibrosis (PMF) is a disease from the group of Ph–negative myeloproliferative tumors, which is characterized by bone marrow fibrosis, splenomegaly and extramedullary hematopoiesis. The mean life in PMF ranges from 7.6 to 10 years and varies widely depending on the appearance of additional mutations and a higher degree of malignancy. Most patients have an indolent flow, and in some patients with PMF, the disease progresses rapidly with the development of acute myeloblastic leukemia. The international stratification system DIPSS-plus allows predicting the occurrence time of the PMF blast transformation phase. The article presents a case of early PMF transformation into acute myeloblastic leukemia in a patient with a heterozygous mutation in the JAK2 gene and an intermediate risk-2 established according to the International Prognostic Scoring DIPSS-plus. The patient received standard cytoreductive therapy.
© The Authors, published by EDP Sciences, 2023
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