| Issue |
BIO Web Conf.
Volume 75, 2023
The 5th International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering (BioMIC 2023)
|
|
|---|---|---|
| Article Number | 02004 | |
| Number of page(s) | 5 | |
| Section | Biomedical Sciences and Engineering | |
| DOI | https://doi.org/10.1051/bioconf/20237502004 | |
| Published online | 15 November 2023 | |
In Silico Destruction of Porphyromonas gingivalis Fimbriae by Streptomyces sp. Strain GMY02
1 Doctoral Program, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia
2 Department of Dental Medicine, Faculty of Medicine, Jenderal Soedirman University, Purwokerto, Indonesia
3 Department of Oral Medicine, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia
4 Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
5 Department of Microbiology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
6 Department of Microbiology, Faculty of Agriculture, Universitas Gadjah Mada, Yogyakarta, Indonesia
7 Research Center for Food Technology and Processing, Research Center for Food Technology and Processing, National Research and Innovation Agency, Gunungkidul, Indonesia
8 Department of Oral Biology, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia
* Corresponding author: henisusilowati@ugm.ac.id
Porphyromonas gingivalis, a keystone pathogen in chronic periodontitis, has fimbria as one of the most important virulence factors because it plays a vital role in the pathogenesis of P. gingivalis infection. This bacterium has 2 fimbriae: the major (FimA) and minor (Mfa1) fimbriae. Fimbriae are attractive targets for anti-infective therapy for periodontal disease. The aim of this study was to analyze the interactions of several compounds thought to be present in Streptomyces sp. GMY02 strain against FimA and Mfa1 proteins in P. gingivalis fimbriae in silico. A total of 8 ligands were docked to FimA and Mfa1 fimbriae using AutoDock Vina in University of California, San Francisco (UCSF) Chimera 1.16. All of the selected ligands had higher free energy values than metronidazole as well. In conclusion, the compounds suspected to be present in Streptomyces sp. strain GMY02 has the potential to destruct P. gingivalis fimbriae.
Key words: Streptomyces / Porphyromonas gingivalis / fimbriae / molecular docking / biofilm
© The Authors, published by EDP Sciences, 2023
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