Functional polymorphisms of oxidative stress and repair genes as biomarkers of the risk of developing breast cancer

Kadyrov Chechen State University, Grozny, Russia

^* Corresponding author: petimat-lg@rambler.ru

Abstract

Breast cancer has the highest incidence and is the fifth leading cause of death in women worldwide. Cancer formation is a multistep, multistep process involving cellular and molecular events. At all its stages, in an initially healthy single cell, there is a gradual accumulation of genetic changes in DNA caused by endogenous and exogenous factors. Breast cancer-predisposing mutations are not evenly distributed among populations, and each ethnic group is descended from its own pool of ancestors who carried a unique spectrum of alleles associated with the disease, making it imperative that studies of this kind be conducted to identify “population-specific markers.”