The Cardioprotective Effect of Polysaccharide Sulphate Isolated from Brown Algae (Sargassum polycystum)

¹ Faculty of Pharmacy, Hasanuddin University, Jl. Perintis Kemerdekaan No.KM 10, 90245 Makassar, Indonesia
² Faculty of Fisheries and Marine Sciences Bogor Agricultural University, Jl. Agatis, 16680 Bogor, Indonesia
³ Faculty of Pharmacy, Gadjah Mada University, Jalan Sekip Utara, 55281 Yogyakarta, Indonesia
⁴ Faculty of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Königin-Luise-Straße 28-30, 14195 Berlin, Germany

^* Corresponding author: mariantimanggau@unhas.ac.id

Abstract

The incidence of atherosclerosis is characterized by an increase in the value of low-density lipoprotein (LDL) and a decrease in the value of high-density lipoprotein (HDL) as well as an increase in the total white blood cell count which can indicate the occurrence of atherosclerosis. This study used 18 rats which were divided into 6 groups of 3 each, namely a normal control group, a negative control group (CMC 0.5%), a positive control group (Simvastatin 20 mg/kg BW), and 3 groups given a sulfate polysaccharide isolate compound test material (dosage of 250, 50, and 10 mg/kg of body weight). The results showed that sulfated polysaccharide isolates had an effect in reducing white blood cells significantly between doses of 250 mg/kg BW and 50 mg/kg BW as well as reducing SGOT levels. Unfortunately it did not reduce the SGPT level. The results of the Mann-Whitney post hoc test showed that administration of sulfated polysaccharides at an optimal dose of 250 mg/kg BW reduced the number of foam cells in the atherosclerotic white rats' (Rattus norvegicus) aortas that were given a high-fat diet and had activity in reducing CKMB levels compared to other doses.