Correction of cognitive function of laboratory rats with diabetes with extracts of nettle and ginkgo biloba

Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan

^* Corresponding author: zhaparkulova.nazgul@kaznu.kz

Abstract

Scientists have objectively demonstrated memory and attention impairments in patients with diabetes mellitus (DM). Currently, neuropsychological testing of patients with diabetes reveals more pronounced impairments in cognitive functions. In the treatment of diabetes mellitus, the use of low-toxic hypoglycemic drugs of plant origin is effective, which not only reduce blood glucose levels, but also have a pleiotropic effect, in particular, normalize cognitive functions. The study showed the optimal effect of nettle extract and ginkgo biloba to normalize cognitive impairment in laboratory rats with hyperglycemia. 3-month-old laboratory white male rats weighing 250-300 g, nettle extract (natural, organic, healthy products), ginkgo biloba extract (Leovit) were used as the object of the study. A test was conducted in a T-shaped maze evaluating the rats’ learning ability and working memory, an outdoor test evaluating motor activity and spatial orientation, an adhesion test evaluating tactile sensitivity and fine motor skills, and a balloon burying test.