Effect of Gender on Cholesterol Levels in Type 2 Diabetes Mellitus Patients

¹ Medicinal Laboratory Technology, Faculty of Health, University Nahdlatul Ulama Surabaya, Indonesia
² Nursing Laboratory, Faculty of Nursing and Midwifery, Universitas Nahdlatul Ulama Surabaya, Indonesia
³ Occupational Health and Safety Laboratory, Faculty of Health, Universitas Nahdlatul Ulama Surabaya, Indonesia

^* Corresponding author: anggrek@unusa.ac.id

Abstract

In women aged 17-50 years, a decrease in Follicle-stimulating hormone (FSH) levels will increase the hormone estrogen which requires cholesterol, so that cholesterol becomes low through inhibition of liver cholesterol biosynthesis. The purpose of this study was to determine differences in cholesterol levels between women and men with Type 2 Diabetes Mellitus. The study design was a cross-sectional analytic observational and purposive sampling technique with inclusion criteria of HbA1c > 6.5%. As a result, the average age of the male respondents was 44 years (SD±18.4), HbA1c 8.5% (SD±2.4), and cholesterol 212 mg/dL (SD±40), the average age of females was 58 years old (SD ± 7.7, HbA1c 10.6% (SD ± 3.4), and cholesterol 181 mg/dL (SD ± 37.6). The results of the Mann- Whitney test with p = 0.038 (p <0.05) mean that there is a significant difference in cholesterol levels between men and women, which means there are differences in how the brain works between men and premenopausal women who suffer from type 2 Diabetes Mellitus Suggestions for future researchers, it is necessary to conduct research on High-sensitivity C-reactive protein (hs-CRP) and low-density lipoprotein (LDL) cholesterol in premenopausal women regarding the role of estrogen and FSH in regulating cholesterol.