| Issue |
BIO Web Conf.
Volume 184, 2025
The 3rd International Seminar of the Indonesian Society for Biochemistry and Molecular Biology (ISISBMB 2025)
|
|
|---|---|---|
| Article Number | 01004 | |
| Number of page(s) | 6 | |
| Section | Health Biochemistry | |
| DOI | https://doi.org/10.1051/bioconf/202518401004 | |
| Published online | 12 August 2025 | |
The effect of vitamin D supplementation on serum vitamin D and interleukin-6 levels in diabetes mellitus-induced rats
1 Department of Biochemistry and Nutrition, Faculty of Medicine, Universitas Baiturrahmah, Padang, West Sumatera, Indonesia
2 Department of Anatomy, Physiology, and Radiology, Faculty of Medicine, Universitas Baiturrahmah, Padang, West Sumatera, Indonesia
3 Department of Internal Medicine, Faculty of Medicine, Universitas Baiturrahmah, Padang, West Sumatera, Indonesia
4 Department of Histology and Immunology, Faculty of Medicine, Universitas Baiturrahmah, Padang, West Sumatra, Indonesia
* Corresponding author: widia_sari@fk.unbrah.ac.id
One of the hallmarks of DM-related inflammation is the elevated production of pro-inflammatory cytokines, such as interleukin-6 (IL-6). Recent evidence has suggested that vitamin D, a fat-soluble secosteroid hormone, may modulate immune responses and inflammatory processes. this study aimed to investigate the effects of different doses of vitamin D supplementation on serum vitamin D levels and IL-6 concentrations in DM-induced rats. An in vitro study was conducted on 15 DM-induced rats, divided into three groups: DM without treatment, DM treated with oral vitamin D at 415 IU, and DM treated with oral vitamin D at 1100 IU. Serum vitamin D and IL-6 levels were measured post-treatment. The Kruskal-Wallis test showed significant differences in serum vitamin D levels among the groups (p = 0.016). ANOVA indicated significant differences in IL-6 levels among groups (p=0.017). Spearman correlation analysis demonstrated a negative correlation between serum vitamin D and IL-6 levels (r= -0.542, p=0.037). The findings suggest that higher doses of vitamin D may have more pronounced anti-inflammatory effects, highlighting its potential role in managing inflammation in diabetes mellitus. Keywords: diabetic rat, interleukin-6, Vitamin D
© The Authors, published by EDP Sciences, 2025
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