Annona Muricata L. Leaf Extract Affects the Number of Neurons in the Temporal Lobe of Adult Wistar Rats Exposed to Noise

¹ Anatomy Departement, Faculty of Medicine and Health Sciences, Universitas Warmadewa, Denpasar, Indonesia.
² Lyceum of the Philippines – Davao (LPU-Davao)

Abstract

By producing free radicals, noise is a major environmental stressor that causes oxidative stress. Long-term exposure to high decibel levels can harm the neurological system as well as other extra-auditory organs of the body. Antioxidant chemicals found in Annona muricata L., popularly known as soursop, may have neuroprotective benefits against oxidative damage. The purpose of this study is to assess how the leaf extract of Annona muricata L. affects the quantity of neurons in the temporal lobe of adult Wistar rats who have been exposed to noise. Thirty male Wistar rats were split into treatment and control groups after a posttest-only control group design. Over the course of 14 days, both groups were subjected to 95 dB noise for four hours every day. Leaf extract from Annona muricata L. was also given to the treatment group. An independent t-test was used to compare the histologically determined neuronal numbers in the temporal lobe. This research show there were much more temporal lobe neurons in the treatment group than in the control group (p = 0.003). Because of its antioxidant qualities, Annona muricata L. leaf extract may have neuroprotective effects against noise-induced brain damage.