Various Synthesis of Imidazo[1,2-a]pyridines Derivatives and Therapeutic Significance: A Review

¹ Applied Chemistry Research Unit, FSTH, Abdelmalek Essaâdi University, AL Hoceima, Tetouan, Morocco.
² Laboratory of Engineering Sciences and Applications, ENSAH, Abdelmalek Essaadi University, Al Hoceima, Morocco
³ Laboratory of Molecular Chemistry, Materials and Environment (LCM2E),Departement of chemistry, Multidisciplinary Faculty of Nador, University Mohamed I, 60700 Nador, Morocco

Abstract

The synthesis of bicyclic heterocycles, notably nitrogen-containing imidazopyridines, holds immense appeal due to their structural diversity and pivotal role in biological systems. These compounds are ubiquitously found in nature and are prized for their significance in both chemical and biological contexts. Imidazopyridine derivatives, among nitrogen heterocycles, serve as fundamental structures in various applications spanning pharmaceuticals to food additives. Consequently, their synthesis and modification represent a focal point in both natural and synthetic organic chemistry. This review aims to comprehensively explore conventional methodologies alongside innovative synthesis approaches, while also delving into the diverse biological properties exhibited by these versatile heterocycles. Through this examination, we endeavor to provide valuable insights that will contribute to further advancements in the synthesis and utilization of imidazopyridines in various fields.