Innate immune response of host cells infected with Salmonella

¹ School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300133, China
² Zhejiang Research Institute of Tianjin University (Shaoxing), Shaoxing 312300, China
³ School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China

^* Corresponding author: songwenjun@tjcu.edu.cn

Abstract

Salmonella is one of the most common pathogenic bacteria with a wide range of hosts and can be transmitted by various routes, infecting animals and humans and causing a range of gastrointestinal and systemic diseases. The innate immune system acts as the frontline defense against pathogenic bacteria, triggering inflammatory and antimicrobial responses by coordinating multiple signaling pathways through host pattern recognition receptors. The success of Salmonella infection is largely dependent on the host’s innate immune defense. This article reviews the process of Salmonella infection and the innate immune defense response of host cells infected with Salmonella.