Evaluation of the Effect of a New Fully Biodegradable External Dressing for Promoting Diabetic Ulcerative Wound Healing

¹ Navy Special Medical Center, Naval Medical University Shanghai, China
² Naval Medical University Shanghai, China
³ Translational Medicine Research Center, Naval Medical University Shanghai, China
⁵ Beijing Key Laboratory of Agricultural Genetic Resources and Biotechnology, Institute of Biotechnology Beijing Academy of Agriculture and Forestry Sciences Beijing, China
⁶ Institute of Food Science and Technology, Chinese Academy of Agricultural Science, Beijing, China

^a 13030734@qq.com
^b 3201217451@qq.com
^c liangdong@smmu.edu.cn
^d 2675907764@qq.com
^e 13586636575@163.com
^f mingguiliu@aliyun.com
^g 2986543466@qq.com
^h 2137068091@qq.com
ⁱ 2972765429@qq.com
^j 18187278537@163.com
^k 1653801767@qq.com
^l 1874688017@qq.com
^m 1454721433@qq.com
^* Corresponding author: z-chunhong@163.com

Abstract

In order to verify the effect of the new fully biodegradable external dressing on the repair of diabetes skin wounds and the promotion of wound healing, this study applied sodium alginate hydrogel dressing products which are supplemented with phage and conotoxin analgesic peptides to the skin lesions of diabetes mice, and comprehensively used the quantitative measurement of serological indicators, Image J Tissue section and other techniques to evaluate the effect of the new hydrogel dressing on the repair of diabetes wounds and the promotion of wound healing. The behavioral observation and analysis of mice did not show obvious regularity and difference. According to the results of serum cytokine analysis, functional hydrogel dressings can promote cell regeneration and wound healing in mice. Image J software analysis showed that the healing results of the experimental group were better than those of the negative control group, and the percentage of collagen fiber content showed an upward trend. Through comprehensive evaluation, it can be observed that the new fully biodegradable external dressing has obvious positive effects on wound healing, collagen fiber reconstruction and wound infection prevention of diabetes. The new biodegradable dressing not only promotes wound healing but also solves environmental pollution problems. It meets the sustainable development needs of society and has broad application prospects.