| Issue |
BIO Web Conf.
Volume 111, 2024
2024 6th International Conference on Biotechnology and Biomedicine (ICBB 2024)
|
|
|---|---|---|
| Article Number | 02004 | |
| Number of page(s) | 8 | |
| Section | Biomedical Advances and Personalized Medicine | |
| DOI | https://doi.org/10.1051/bioconf/202411102004 | |
| Published online | 31 May 2024 | |
Retrosynthesis of Wulfenioidins L with Potential Anti-Zika Virus Activity
1 School of Life Science, University of Nottingham, Nottingham NG7 2UH, United Kingdom
2 School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China
* Corresponding author: mbytw6@nottingham.ac.uk
a guyuning2002@g mail.com
The paper discusses the retrosynthesis of Wulfenioidin L, a compound showing potential anti-Zika virus activity. Wulfenioidins were isolated from Orthosiphon wulfenioides, with some demonstrating virus entry inhibition. The paper focuses on Wulfenioidin L due to its relative potency and fewer pharmacokinetic challenges compared to others. It presents significant synthesis challenges, including its polycyclic structure with chiral centers and multiple substituents. The study proposes two retrosynthetic pathways for Wulfenioidin L, involving complex reactions like Diels-Alder and oxidation. The synthesis approach also addresses issues like regioselectivity, yield optimization, and environmentally friendly practices.
© The Authors, published by EDP Sciences, 2024
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